catalog number :
MBS710020
products full name :
Rabbit anti-human ecto-NOX disulfide-thiol exchanger 2 polyclonal Antibody
products short name :
ecto-NOX disulfide-thiol exchanger 2
products name syn :
ecto-NOX disulfide-thiol exchanger 2; ENOX2; APK1; COVA1; tNOX
other names :
Ecto-NOX disulfide-thiol exchanger 2; Ecto-NOX disulfide-thiol exchanger 2; ecto-NOX disulfide-thiol exchanger 2; APK1 antigen; cytosolic ovarian carcinoma antigen 1; tumor-associated hydroquinone oxidase; ecto-NOX disulfide-thiol exchanger 2; APK1 antigen; Cytosolic ovarian carcinoma antigen 1; Tumor-associated hydroquinone oxidase; tNOX
other gene names :
ENOX2; ENOX2; APK1; tNOX; COVA1; COVA1; tNOX
uniprot entry name :
ENOX2_HUMAN
reactivity :
Human,Mouse,Rat; Other species are not tested. Please decide the specificity by homology.
sequence positions :
Shipped at 4 degree C Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
purity :
Antigen Affinity Purified
tested application :
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
app notes :
ELISA: Use at an assay dependent dilution. WB : 1:500-1:5000 . IP : 1:200-1:2000 . IHC : 1:20-1:200 (Recommender dilutions) . Positive WB detected in : MCF-7 cells, HeLa cells, mouse ovary tissue, PC-3 cells . Positive IP detected in : MCF-7 cells . Positive IHC detected in : Human ovary tumor tissue
other info1 :
Immunogen: Human ENOX2. Conjugate : Non-conjugated
other info2 :
Storage Buffer: PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
products description :
May be involved in cell growth. Probably acts as a terminal oxidase of plasma electron transport from cytosolic NAD(P)H via hydroquinones to acceptors at the cell surface. Hydroquinone oxidase activity alternates with a protein disulfide-thiol interchange/oxidoreductase activity which may control physical membrane displacements associated with vesicle budding or cell enlargement. The activities oscillate with a period length of 22 minutes and play a role in control of the ultradian cellular biological clock.
ncbi acc num :
AAI40875.1
ncbi summary :
This gene is a tumor-specific member of the ECTO-NOX family of genes that encode cell surface NADH oxidases. The encoded protein has two enzymatic activities: catalysis of hydroquinone or NADH oxidation, and protein disulfide interchange. The protein also displays prion-like properties. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
uniprot summary :
ENOX2: May be involved in cell growth. Probably acts as a terminal oxidase of plasma electron transport from cytosolic NAD(P)H via hydroquinones to acceptors at the cell surface. Hydroquinone oxidase activity alternates with a protein disulfide- thiol interchange/oxidoreductase activity which may control physical membrane displacements associated with vesicle budding or cell enlargement. The activities oscillate with a period length of 22 minutes and play a role in control of the ultradian cellular biological clock. Belongs to the ENOX family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Oxidoreductase; EC 1.-.-.-; Cytoskeletal; Cell surface. Chromosomal Location of Human Ortholog: Xq25. Cellular Component: extracellular space; cytosol; external side of plasma membrane. Molecular Function: nucleic acid binding; nucleotide binding; protein disulfide oxidoreductase activity. Biological Process: regulation of growth; cell growth; ultradian rhythm