product summary
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company name :
MyBioSource
product type :
ELISA/assay
product name :
Human soluble tumor necrosis factor-like weak inducer of apoptosis, sTWEAK ELISA Kit
catalog :
MBS705898
quantity :
96-Strip-Wells
price :
915 USD
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS705898
products type :
ELISA Kit
products full name :
Human soluble tumor necrosis factor-like weak inducer of apoptosis, sTWEAK ELISA Kit
products short name :
tumor necrosis factor (ligand) superfamily, member 12
products name syn :
Human soluble tumor necrosis factor-like weak inducer of apoptosis (sTWEAK) ELISA Kit; APO3L; DR3LG; MGC129581; MGC20669; TWEAK; APO3/DR3 ligand; TNF-related WEAK inducer of apoptosis; tumor necrosis factor (ligand) superfamily; member 12
other names :
tumor necrosis factor ligand superfamily member 12 proprotein; Tumor necrosis factor ligand superfamily member 12; tumor necrosis factor ligand superfamily member 12; APO3 ligand; APO3/DR3 ligand; TNF-related WEAK inducer of apoptosis; tumor necrosis factor (ligand) superfamily, member 12; APO3 ligand; TNF-related weak inducer of apoptosis; TWEAK
products gene name :
TNFSF12
other gene names :
TNFSF12; TNFSF12; APO3L; DR3LG; TWEAK; APO3L; DR3LG; UNQ181/PRO207; TWEAK
uniprot entry name :
TNF12_HUMAN
reactivity :
Human
sequence length :
249
specificity :
This assay has high sensitivity and excellent specificity for detection of Human TNFSF12. No significant cross-reactivity or interference between Human TNFSF12 and analogues was observed.
storage stability :
Unopened test kits should be stored at 2 to 8 degree C upon receipt. Please refer to pdf manual for further storage instructions.
other info1 :
Samples: Serum, plasma. Detection Range: 0.156 ng/ml-10 ng/ml. Sensitivity: 0.039 ng/ml
other info2 :
Intra-assay Precision: Intra-assay Precision (Precision within an assay): CV% is less than 8%. Three samples of known concentration were tested twenty times on one plate to assess. Inter-assay Precision (Precision between assays): CV% is less than 10%. Three samples of known concentration were tested in twenty assays to assess. Detection Wavelength: 450 nm. Sample Volume: 50-100ul. Protein Biological Process 1: Angiogenesis. Protein Biological Process 3: Angiogenesis
ncbi gi num :
4507597
ncbi acc num :
NP_003800.1
ncbi gb acc num :
NM_003809.2
uniprot acc num :
O43508
ncbi mol weight :
27,216 Da
ncbi pathways :
Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); Gene Expression Pathway (105937); HuR Stabilizes MRNA Pathway (187216); Regulation Of MRNA Stability By Proteins That Bind AU-rich Elements Pathway (187211); TWEAK Signaling Pathway (672452)
ncbi summary :
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is a ligand for the FN14/TWEAKR receptor. This cytokine has overlapping signaling functions with TNF, but displays a much wider tissue distribution. This cytokine, which exists in both membrane-bound and secreted forms, can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. This cytokine is also found to promote proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis. Alternative splicing results in multiple transcript variants. Some transcripts skip the last exon of this gene and continue into the second exon of the neighboring TNFSF13 gene; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13. [provided by RefSeq, Oct 2010]
uniprot summary :
Function: Binds to FN14 and possibly also to TNRFSF12/APO3. Weak inducer of apoptosis in some cell types. Mediates NF-kappa-B activation. Promotes angiogenesis and the proliferation of endothelial cells. Also involved in induction of inflammatory cytokines. Promotes IL8 secretion.2 PublicationsManual assertion based on experiment in:Ref.7
size1 :
96-Strip-Wells
price1 :
915 USD
size2 :
5x96-Strip-Wells
price2 :
2565
size3 :
10x96-Strip-Wells
price3 :
4800
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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