Human Interleukin 37, IL-37 ELISA Kit | MyBioSource MBS705712 product information

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Human Interleukin 37, IL-37 ELISA Kit

catalog :

MBS705712

quantity :

48-Strip-Wells

price :

510 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS705712

products type :

ELISA Kit

products full name :

Human Interleukin 37, IL-37 ELISA Kit

products short name :

interleukin 1 family, member 7 (zeta)

products name syn :

Human Interleukin 37 (IL-37) ELISA Kit; FIL1; FIL1 (ZETA); FIL1Z; IL-1F7; IL-1H4; IL-1RP1; IL1H4; IL1RP1; IL-1F7b (IL-1H4; IL-1H; IL-1RP1) ; IL-1X protein; IL1F7 (canonical product IL-1F7b) ; interleukin 1 family member 7; interleukin 1 family; ; interleukin 1 family; member 7 (zeta)

other names :

interleukin-37 isoform 1; Interleukin-37; interleukin-37; FIL1 zeta; IL-1 zeta; IL-1X protein; interleukin-23; interleukin 1, zeta; interleukin-1 homolog 4; interleukin-1 superfamily z; interleukin 1 family member 7; interleukin-1-related protein; IL-1F7b (IL-1H4, IL-1H, IL-1RP1); IL1F7 (canonical product IL-1F7b); interleukin 37; FIL1 zeta; IL-1X; Interleukin-1 family member 7; IL-1F7; Interleukin-1 homolog 4; IL-1H; IL-1H4; Interleukin-1 zeta; IL-1 zeta; Interleukin-1-related protein; IL-1RP1; Interleukin-23; IL-37

products gene name :

IL1F7

other gene names :

IL37; IL37; FIL1; FIL1Z; IL-1H; IL-37; IL1F7; IL1H4; IL-1F7; IL-1H4; IL1RP1; IL-1RP1; FIL1(ZETA); FIL1Z; IL1F7; IL1H4; IL1RP1; IL-1F7; IL-1H; IL-1H4; IL-1 zeta; IL-1RP1; IL-37

uniprot entry name :

IL37_HUMAN

reactivity :

Human

sequence length :

218

specificity :

This assay has high sensitivity and excellent specificity for detection of human IL-37. No significant cross-reactivity or interference between human IL-37 and analogues was observed.

storage stability :

Unopened test kits should be stored at 2 to 8 degree C upon receipt. Please refer to pdf manual for further storage instructions.

other info1 :

Samples: Serum, plasma, cell culture supernates. Assay Type: Sandwich. Detection Range: 31.25 pg/ml -2000 pg/ml. Sensitivity: The minimum detectable dose of human IL-37 is typically less than 7.81 pg/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations.

other info2 :

Intra-assay Precision: Intra-assay Precision (Precision within an assay): CV%<8%. Three samples of known concentration were tested twenty times on one plate to assess. Inter-assay Precision: Inter-assay Precision (Precision between assays): CV%<10%. Three samples of known concentration were tested in twenty assays to assess.

products description :

Principle of the Assay: This assay employs the quantitative sandwich enzyme immunoassay technique. Antibody specific for IL-37 has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and any IL-37 present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for IL-37 is added to the wells. After washing, avidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of IL-37 bound in the initial step. The color development is stopped and the intensity of the color is measured.

ncbi gi num :

20127524

ncbi acc num :

NP_055254.2

ncbi gb acc num :

NM_014439.3

uniprot acc num :

Q9NZH6

ncbi mol weight :

24,126 Da

ncbi summary :

The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine can bind to, and may be a ligand for interleukin 18 receptor (IL18R1/IL-1Rrp). This cytokine also binds to interleukin 18 binding protein (IL18BP), an inhibitory binding protein of interleukin 18 (IL18), and subsequently forms a complex with IL18 receptor beta subunit, and through which it inhibits the activity of IL18. This gene along with eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Five alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

uniprot summary :

Function: Suppressor of innate inflammatory and immune responses involved in curbing excessive inflammation. This function requires SMAD3. Suppresses, or reduces, proinflammatory cytokine production, including IL1A and IL6, as well as CCL12, CSF1, CSF2, CXCL13, IL1B, IL23A and IL1RN, but spares anti-inflammatory cytokines. Inhibits dendritic cell activation.2 PublicationsManual assertion based on experiment in:Ref.11

size1 :

48-Strip-Wells

price1 :

510 USD

size2 :

96-Strip-Wells

price2 :

725

size3 :

5x96-Strip-Wells

price3 :

2565

size4 :

10x96-Strip-Wells

price4 :

4800

more info or order :

MyBioSource product webpage