Human sphingosine 1-phosphate receptor type 1, S1P1 ELISA Kit | MyBioSource MBS705455 product information

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Human sphingosine 1-phosphate receptor type 1, S1P1 ELISA Kit

catalog :

MBS705455

quantity :

96 Strip Wells

price :

760 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS705455

products type :

ELISA Kit

products full name :

Human sphingosine 1-phosphate receptor type 1, S1P1 ELISA Kit

products short name :

sphingosine-1-phosphate receptor 1

products name syn :

Human sphingosine 1-phosphate receptor type 1 (S1P1) ELISA Kit; CHEDG1; D1S3362; ECGF1; EDG-1; EDG1; FLJ58121; S1P1; endothelial differentiation; sphingolipid G-protein-coupled receptor; 1; sphingosine 1-phosphate receptor EDG1; sphingosine-1-phosphate receptor 1

other names :

sphingosine 1-phosphate receptor 1; Sphingosine 1-phosphate receptor 1; sphingosine 1-phosphate receptor 1; S1P receptor 1; S1P receptor Edg-1; sphingosine 1-phosphate receptor EDG1; sphingosine 1-phosphate receptor Edg-1; endothelial differentiation G-protein coupled receptor 1; endothelial differentiation, sphingolipid G-protein-coupled receptor, 1; sphingosine-1-phosphate receptor 1; Endothelial differentiation G-protein coupled receptor 1; Sphingosine 1-phosphate receptor Edg-1; S1P receptor Edg-1; CD_antigen: CD363

products gene name :

S1PR1

other gene names :

S1PR1; S1PR1; EDG1; S1P1; CD363; ECGF1; EDG-1; CHEDG1; D1S3362; CHEDG1; EDG1; S1P receptor 1; S1P1; S1P receptor Edg-1

uniprot entry name :

S1PR1_HUMAN

reactivity :

Human

sequence length :

382

specificity :

This assay has high sensitivity and excellent specificity for detection of Human S1PR1. No significant cross-reactivity or interference between Human S1PR1 and analogues was observed.

storage stability :

Unopened test kits should be stored at 2 to 8 degree C upon receipt. Please refer to pdf manual for further storage instructions.

other info1 :

Intra-assay Precision: Intra-assay Precision (Precision within an assay): CV% is less than 8%. Three samples of known concentration were tested twenty times on one plate to assess. Inter-assay Precision (Precision between assays): CV% is less than 10%. Three samples of known concentration were tested in twenty assays to assess. Sample Type: serum, plasma, tissue homogenates, cell lysates. Detection Range: 25 pg/ml-1600 pg/ml. Detection Wavelength: 450 nm. Sensitivity: 6.25 pg/ml

other info2 :

Sample Volume: 50-100ul

ncbi gi num :

13027636

ncbi acc num :

NP_001391.2

ncbi gb acc num :

NM_001400.4

uniprot acc num :

P21453

ncbi mol weight :

42,811 Da

ncbi pathways :

Class A/1 (Rhodopsin-like Receptors) Pathway 106357!!Fc-epsilon Receptor I Signaling In Mast Cells Pathway 138050!!FoxO Signaling Pathway 921162!!G Alpha (i) Signalling Events Pathway 119550!!GPCR Downstream Signaling Pathway 119548!!GPCR Ligand Binding Pathway 161020!!GPCRs, Other Pathway 198765!!Lysosphingolipid And LPA Receptors Pathway 106376!!Neuroactive Ligand-receptor Interaction Pathway 83053!!Neuroactive Ligand-receptor Interaction Pathway 462

ncbi summary :

The protein encoded by this gene is structurally similar to G protein-coupled receptors and is highly expressed in endothelial cells. It binds the ligand sphingosine-1-phosphate with high affinity and high specificity, and suggested to be involved in the processes that regulate the differentiation of endothelial cells. Activation of this receptor induces cell-cell adhesion. [provided by RefSeq, Jul 2008]

uniprot summary :

Function: G-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that seems to be coupled to the G(i) subclass of heteromeric G proteins. Signaling leads to the activation of RAC1, SRC, PTK2/FAK1 and MAP kinases. Plays an important role in cell migration, probably via its role in the reorganization of the actin cytoskeleton and the formation of lamellipodia in response to stimuli that increase the activity of the sphingosine kinase SPHK1. Required for normal chemotaxis toward sphingosine 1-phosphate. Required for normal embryonic heart development and normal cardiac morphogenesis. Plays an important role in the regulation of sprouting angiogenesis and vascular maturation. Inhibits sprouting angiogenesis to prevent excessive sprouting during blood vessel development. Required for normal egress of mature T-cells from the thymus into the blood stream and into peripheral lymphoid organs. Plays a role in the migration of osteoclast precursor cells, the regulation of bone mineralization and bone homeostasis Plays a role in responses to oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine by pulmonary endothelial cells and in the protection against ventilator-induced lung injury.8 PublicationsManual assertion based on experiment in:Ref.3

size :

96 Strip Wells

price :

760 USD

more info or order :

MyBioSource product webpage