PSEN2 Antibody | MyBioSource MBS7052325 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

PSEN2 Antibody

catalog :

MBS7052325

quantity :

0.05 mg

price :

160 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, rat

application :

western blot, ELISA, enzyme immunoassay

more info or order :

MyBioSource product webpage

image

image 1 :

Western Blot. Positive WB detected in: Rat spleen tissue,Rat lung tissue. All lanes: PSEN2 antibody at 3ug/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 51,47 KDa. Observed band size: 51 KDa.

product information

catalog number :

MBS7052325

products type :

Antibody

products full name :

PSEN2 Antibody

products short name :

[PSEN2]

products name syn :

[Presenilin-2; PS-2; AD3LP; AD5; E5-1; STM-2; Presenilin-2 NTF subunit; Presenilin-2 CTF subunit; PSEN2; AD4; PS2; PSNL2; STM2]

other names :

[presenilin-2 isoform 1; Presenilin-2; presenilin-2; presenilin 2; AD3LP; AD5; E5-1; STM-2]

products gene name :

[PSEN2]

other gene names :

[PSEN2; PSEN2; AD4; PS2; AD3L; STM2; CMD1V; AD4; PS2; PSNL2; STM2; PS-2]

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human, Rat

sequence length :

448

purity :

>95%, Protein G purified

form :

Liquid

storage stability :

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

tested application :

ELISA (EIA), Western Blot (WB)

app notes :

Recommended dilution: WB: 1:500-1:5000

image1 heading :

Western Blot (WB)

other info1 :

Immunogen: Recombinant Human Presenilin-2 protein (7-77AA). Conjugation: Non-conjugated

other info2 :

Preservative: 0.03% Proclin 300. Constituents: 50% Glycerol, 0.01M PBS, pH 7.4. Species: Human. Research Area: Neuroscience

products description :

Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins.

ncbi gi num :

156105679

ncbi acc num :

NP_000438.2

ncbi gb acc num :

NM_000447.2

uniprot acc num :

P49810

ncbi pathways :

Activated NOTCH1 Transmits Signal To The Nucleus Pathway (576270); Alzheimer's Disease Pathway (83097); Alzheimer's Disease Pathway (509); Alzheimers Disease Pathway (672448); Cell Death Signalling Via NRAGE, NRIF And NADE Pathway (106443); Constitutive Signaling By NOTCH1 HD+PEST Domain Mutants Pathway (771595); Constitutive Signaling By NOTCH1 PEST Domain Mutants Pathway (771593); Delta-Notch Signaling Pathway (198879); Disease Pathway (530764); FBXW7 Mutants And NOTCH1 In Cancer Pathway (771596)

ncbi summary :

Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified. [provided by RefSeq, Jul 2008]

uniprot summary :

PSEN2: probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). An integral membrane protein of the Golgi and endoplasmic reticulum. Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins. Two alternative splice isoforms have been identified. Protein type: Cell surface; EC 3.4.23.-; Membrane protein, integral; Membrane protein, multi-pass; Protease. Chromosomal Location of Human Ortholog: 1q42.13. Cellular Component: apical plasma membrane; cell cortex; cell soma; centrosome; endoplasmic reticulum; Golgi apparatus; integral to plasma membrane; kinetochore; membrane; nuclear inner membrane; perinuclear region of cytoplasm; plasma membrane; protein complex; Z disc. Molecular Function: endopeptidase activity; protein binding. Biological Process: amyloid precursor protein catabolic process; beta-amyloid metabolic process; calcium ion transport; ephrin receptor signaling pathway; membrane protein ectodomain proteolysis; membrane protein intracellular domain proteolysis; negative regulation of apoptosis; Notch receptor processing; Notch signaling pathway; positive regulation of apoptosis; positive regulation of catalytic activity; protein processing. Disease: Alzheimer Disease 4; Cardiomyopathy, Dilated, 1v

size1 :

0.05 mg

price1 :

160 USD

size2 :

0.1 mg

price2 :

235

more info or order :

MyBioSource product webpage