catalog number :
MBS7052153
products full name :
MNDA Antibody
products short name :
[MNDA]
products name syn :
[Myeloid cell nuclear differentiation antigen; MNDA]
other names :
[myeloid cell nuclear differentiation antigen; Myeloid cell nuclear differentiation antigen; myeloid cell nuclear differentiation antigen; myeloid cell nuclear differentiation antigen]
products gene name :
[MNDA]
other gene names :
[MNDA; MNDA; PYHIN3]
reactivity :
Human, Mouse
purity :
>95%, Protein G purified
storage stability :
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
tested application :
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
app notes :
WB: 1:500-1:5000. IHC: 1:20-1:200. IF: 1:50-1:200
image1 heading :
Western Blot (WB)
image2 heading :
Immunohistochemistry (IHC)
image3 heading :
Immunohistochemistry (IHC)
other info1 :
Immunogen: Recombinant Human Myeloid cell nuclear differentiation antigen protein (84-233AA). Conjugation: Non-conjugated. Species: Human. Research Area: Immunology. Target Names: MNDA
other info2 :
Buffer: Preservative: 0.03% Proclin 300. Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
products description :
May act as a transcriptional activator/repressor in the myeloid lineage. Plays a role in the granulocyte/monocyte cell-specific response to interferon. Stimulates the DNA binding of the transcriptional repressor protein YY1.
ncbi acc num :
NP_002423.1
ncbi gb acc num :
NM_002432.2
ncbi summary :
The myeloid cell nuclear differentiation antigen (MNDA) is detected only in nuclei of cells of the granulocyte-monocyte lineage. A 200-amino acid region of human MNDA is strikingly similar to a region in the proteins encoded by a family of interferon-inducible mouse genes, designated Ifi-201, Ifi-202, and Ifi-203, that are not regulated in a cell- or tissue-specific fashion. The 1.8-kb MNDA mRNA, which contains an interferon-stimulated response element in the 5-prime untranslated region, was significantly upregulated in human monocytes exposed to interferon alpha. MNDA is located within 2,200 kb of FCER1A, APCS, CRP, and SPTA1. In its pattern of expression and/or regulation, MNDA resembles IFI16, suggesting that these genes participate in blood cell-specific responses to interferons. [provided by RefSeq, Jul 2008]
uniprot summary :
May act as a transcriptional activator/repressor in the myeloid lineage. Plays a role in the granulocyte/monocyte cell-specific response to interferon. Stimulates the DNA binding of the transcriptional repressor protein YY1.