Human CC-chemokine receptor 1, CCR1 ELISA Kit | MyBioSource MBS705098 product information

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Human CC-chemokine receptor 1, CCR1 ELISA Kit

catalog :

MBS705098

quantity :

48-Strip-Wells

price :

565 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS705098

products type :

ELISA Kit

products full name :

Human CC-chemokine receptor 1, CCR1 ELISA Kit

products short name :

chemokine (C-C motif) receptor 1

products name syn :

Human CC-chemokine receptor 1; CCR1 ELISA Kit; CD191; CKR-1; CKR1; CMKBR1; HM145; MIP1aR; SCYAR1; RANTES receptor; chemokine (C-C motif) receptor 1

other names :

C-C chemokine receptor type 1; C-C chemokine receptor type 1; C-C chemokine receptor type 1; CCR-1; CC-CKR-1; RANTES-R; C-C CKR-1; MIP-1alpha-R; LD78 receptor; RANTES receptor; macrophage inflammatory protein 1-alpha receptor; chemokine (C-C motif) receptor 1; HM145; LD78 receptor; Macrophage inflammatory protein 1-alpha receptor; MIP-1alpha-R; RANTES-R; CD_antigen: CD191

products gene name :

CCR1

other gene names :

CCR1; CCR1; CKR1; CD191; CKR-1; HM145; CMKBR1; MIP1aR; SCYAR1; CMKBR1; CMKR1; SCYAR1; C-C CKR-1; CC-CKR-1; CCR-1; CCR1; MIP-1alpha-R

uniprot entry name :

CCR1_HUMAN

reactivity :

Human

sequence length :

355

specificity :

This assay has high sensitivity and excellent specificity for detection of human CCR1. No significant cross-reactivity or interference between human CCR1 and analogues was observed.

storage stability :

Unopened test kits should be stored at 2 to 8 degree C upon receipt. Please refer to pdf manual for further storage instructions.

other info1 :

Samples: Serum, plasma, tissue homogenates, Cell lysates. Assay Type: Sandwich. Detection Range: 39.06 pg/ml -2500 pg/ml. Sensitivity: The minimum detectable dose of human CCR1 is typically less than 9.77 pg/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations.

other info2 :

Intra-assay Precision: Intra-assay Precision (Precision within an assay): CV%<8%. Three samples of known concentration were tested twenty times on one plate to assess. Inter-assay Precision: Inter-assay Precision (Precision between assays): CV%<10%. Three samples of known concentration were tested in twenty assays to assess.

products description :

Principle of the assay: This assay employs the quantitative sandwich enzyme immunoassay technique. Antibody specific for CCR1 has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and any CCR1 present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for CCR1 is added to the wells. After washing, avidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of CCR1 bound in the initial step. The color development is stopped and the intensity of the color is measured.

ncbi gi num :

4502631

ncbi acc num :

NP_001286.1

ncbi gb acc num :

NM_001295.2

uniprot acc num :

P32246

ncbi mol weight :

41,173 Da

ncbi pathways :

Chemokine Receptors Bind Chemokines Pathway (106359); Chemokine Signaling Pathway (99051); Chemokine Signaling Pathway (96864); Class A/1 (Rhodopsin-like Receptors) Pathway (106357); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); G Alpha (i) Signalling Events Pathway (119550); GPCR Downstream Signaling Pathway (119548); GPCR Ligand Binding Pathway (161020); GPCRs, Class A Rhodopsin-like Pathway (198886)

ncbi summary :

This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The ligands of this receptor include macrophage inflammatory protein 1 alpha (MIP-1 alpha), regulated on activation normal T expressed and secreted protein (RANTES), monocyte chemoattractant protein 3 (MCP-3), and myeloid progenitor inhibitory factor-1 (MPIF-1). Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. Knockout studies of the mouse homolog suggested the roles of this gene in host protection from inflammatory response, and susceptibility to virus and parasite. This gene and other chemokine receptor genes, including CCR2, CCRL2, CCR3, CCR5 and CCXCR1, are found to form a gene cluster on chromosome 3p. [provided by RefSeq, Jul 2008]

uniprot summary :

Function: Receptor for a C-C type chemokine. Binds to MIP-1-alpha, MIP-1-delta, RANTES, and MCP-3 and, less efficiently, to MIP-1-beta or MCP-1 and subsequently transduces a signal by increasing the intracellular calcium ions level. Responsible for affecting stem cell proliferation.

size1 :

48-Strip-Wells

price1 :

565 USD

size2 :

96-Strip-Wells

price2 :

810

size3 :

5x96-Strip-Wells

price3 :

2750

size4 :

10x96-Strip-Wells

price4 :

5150

more info or order :

MyBioSource product webpage