DNAH5 Antibody | MyBioSource MBS7050719 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

DNAH5 Antibody

catalog :

MBS7050719

quantity :

0.05 mg

price :

160 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

ELISA, immunohistochemistry, immunocytochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

image

image 1 :

Immunohistochemistry of paraffin-embedded human lung tissue using MBS7050719 at dilution of 1:100

image 2 :

Immunofluorescent analysis of HepG2 cells using MBS7050719 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

product information

catalog number :

MBS7050719

products type :

Antibody

products full name :

DNAH5 Antibody

products short name :

[DNAH5]

products name syn :

[Dynein heavy chain 5; axonemal; Axonemal beta dynein heavy chain 5; Ciliary dynein heavy chain 5; DNAH5; DNAHC5; HL1; KIAA1603]

other names :

[dynein heavy chain 5, axonemal; Dynein heavy chain 5, axonemal; dynein heavy chain 5, axonemal; dynein axonemal heavy chain 5; Axonemal beta dynein heavy chain 5; Ciliary dynein heavy chain 5]

products gene name :

[DNAH5]

other gene names :

[DNAH5; DNAH5; HL1; PCD; CILD3; KTGNR; DNAHC5; DNAHC5; HL1; KIAA1603]

uniprot entry name :

DYH5_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human

purity :

>95%, Protein G purified

form :

Liquid

storage stability :

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

tested application :

ELISA (EIA), Immunohistochemistry (IHC), Immunofluorescence (IF)

app notes :

IHC: 1: 20-1: 200. IF: 1: 50-1: 200

image1 heading :

Immunohistochemistry (IHC)

image2 heading :

Immunofluorescence (IF)

other info1 :

Immunogen: Recombinant Human Dynein heavy chain 5, axonemal protein (2364-2560AA). Conjugate: Non-conjugated. Storage Buffer: Preservative: 0.03% Proclin 300. Constituents: 50% Glycerol, 0.01M PBS, pH 7.4. Species: Human. Research Area: Signal Transduction

other info2 :

Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-162744 / sc-162747

products description :

Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Required for structural and functional integrity of the cilia of ependymal cells lining the brain ventricles.

ncbi gi num :

19115954

ncbi acc num :

NP_001360.1

ncbi gb acc num :

NM_001369.2

uniprot acc num :

Q8TE73

ncbi pathways :

Huntington's Disease Pathway (83100); Huntington's Disease Pathway (512)

ncbi summary :

This gene encodes a dynein protein, which is part of a microtubule-associated motor protein complex consisting of heavy, light, and intermediate chains. This protein is an axonemal heavy chain dynein. It functions as a force-generating protein with ATPase activity, whereby the release of ADP is thought to produce the force-producing power stroke. Mutations in this gene cause primary ciliary dyskinesia type 3, as well as Kartagener syndrome, which are both diseases due to ciliary defects. [provided by RefSeq, Oct 2009]

uniprot summary :

DNAH5: Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Required for structural and functional integrity of the cilia of ependymal cells lining the brain ventricles. Defects in DNAH5 are the cause of primary ciliary dyskinesia type 3 (CILD3). CILD3 is an autosomal recessive disorder characterized by axonemal abnormalities of motile cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to defects in the respiratory cilia; reduced fertility is often observed in male patients due to abnormalities of sperm tails. Half of the patients exhibit situs inversus, due to dysfunction of monocilia at the embryonic node and randomization of left-right body asymmetry. Primary ciliary dyskinesia associated with situs inversus is referred to as Kartagener syndrome. Defects in DNAH5 are a cause of Kartagener syndrome (KTGS). KTGS is an autosomal recessive disorder characterized by the association of primary ciliary dyskinesia with situs inversus. Clinical features include recurrent respiratory infections, bronchiectasis, infertility, and lateral transposition of the viscera of the thorax and abdomen. The situs inversus is most often total, although it can be partial in some cases (isolated dextrocardia or isolated transposition of abdominal viscera). Belongs to the dynein heavy chain family. Protein type: Microtubule-binding; Motility/polarity/chemotaxis; Motor. Chromosomal Location of Human Ortholog: 5p15.2. Cellular Component: axoneme. Biological Process: determination of left/right symmetry; sperm motility. Disease: Ciliary Dyskinesia, Primary, 3

size1 :

0.05 mg

price1 :

160 USD

size2 :

0.1 mg

price2 :

235

more info or order :

MyBioSource product webpage