SLC30A8 Antibody | MyBioSource MBS7050703 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

SLC30A8 Antibody

catalog :

MBS7050703

quantity :

0.05 mg

price :

160 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

ELISA, immunohistochemistry, immunocytochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

image

image 1 :

Immunohistochemistry of paraffin-embedded human placenta tissue using MBS7050703 at dilution of 1:100

image 2 :

Immunofluorescent analysis of HepG2 cells using MBS7050703 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

product information

catalog number :

MBS7050703

products type :

Antibody

products full name :

SLC30A8 Antibody

products short name :

[SLC30A8]

products name syn :

[Zinc transporter 8ZnT-8; Solute carrier family 30 member 8; SLC30A8; ZNT8]

other names :

[zinc transporter 8 isoform b; Zinc transporter 8; zinc transporter 8; solute carrier family 30 member 8; Solute carrier family 30 member 8]

products gene name :

[SLC30A8]

other gene names :

[SLC30A8; SLC30A8; ZNT8; ZnT-8; ZNT8; ZnT-8]

uniprot entry name :

ZNT8_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human

sequence length :

320

purity :

>95%, Protein G purified

form :

Liquid

storage stability :

Upon receipt store at -20°C or -80°C. Avoid repeated freeze.

tested application :

ELISA (EIA), Immunohistochemistry (IHC), Immunofluorescence (IF)

app notes :

IHC: 1: 20-1: 200. IF: 1: 50-1: 200

image1 heading :

Immunohistochemistry (IHC)

image2 heading :

Immunofluorescence (IF)

other info1 :

Immunogen: Recombinant human Zinc transporter 8 protein (320-369AA). Species: Human

other info2 :

Preservative: 0.03% Proclin 300. Constituents: 50% Glycerol, 0.01M PBS, PH 7.4. Conjugation: Non-conjugated. Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-98243

products description :

Facilitates the accumulation of zinc from the cytoplasm into intracellular vesicles, being a zinc-efflux transporter. May be a major component for providing zinc to insulin maturation and/or storage processes in insulin-secreting pancreatic beta-cells.

ncbi gi num :

289803003

ncbi acc num :

NP_001166282.1

ncbi gb acc num :

NM_001172811.1

uniprot acc num :

Q8IWU4

ncbi pathways :

Insulin Processing Pathway (1268747); Metabolism Of Proteins Pathway (1268677); Metal Ion SLC Transporters Pathway (1269930); Peptide Hormone Metabolism Pathway (1268746); SLC-mediated Transmembrane Transport Pathway (1269907); Transmembrane Transport Of Small Molecules Pathway (1269903); Transport Of Glucose And Other Sugars, Bile Salts And Organic Acids, Metal Ions And Amine Compounds Pathway (1269923); Zinc Efflux And Compartmentalization By The SLC30 Family Pathway (1269932); Zinc Homeostasis Pathway (1458250); Zinc Transporters Pathway (1269931)

ncbi summary :

The protein encoded by this gene is a zinc efflux transporter involved in the accumulation of zinc in intracellular vesicles. This gene is expressed at a high level only in the pancreas, particularly in islets of Langerhans. The encoded protein colocalizes with insulin in the secretory pathway granules of the insulin-secreting INS-1 cells. Allelic variants of this gene exist that confer susceptibility to diabetes mellitus, noninsulin-dependent (NIDDM). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2010]

uniprot summary :

SLC30A8: Facilitates the accumulation of zinc from the cytoplasm into intracellular vesicles, being a zinc-efflux transporter. May be a major component for providing zinc to insulin maturation and/or storage processes in insulin-secreting pancreatic beta- cells. Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family; Vesicle. Chromosomal Location of Human Ortholog: 8q24.11. Cellular Component: cytoplasmic vesicle; Golgi apparatus; plasma membrane; secretory granule; secretory granule membrane. Molecular Function: protein binding; protein homodimerization activity; zinc ion binding; zinc ion transmembrane transporter activity. Biological Process: cellular zinc ion homeostasis; glucose homeostasis; insulin secretion; positive regulation of insulin secretion; response to glucose stimulus; response to zinc ion; sequestering of zinc ion; zinc ion transport. Disease: Diabetes Mellitus, Noninsulin-dependent

size1 :

0.05 mg

price1 :

160 USD

size2 :

0.1 mg

price2 :

235

more info or order :

MyBioSource product webpage