antibody

FOXC1 Antibody, FITC conjugated

MBS7050182

0.05 mg

160 USD

polyclonal

rabbit

FITC

ELISA, enzyme immunoassay

Antibody

FOXC1 Antibody, FITC conjugated

[FOXC1]

[Forkhead box protein C1; Forkhead-related protein FKHL7; Forkhead-related transcription factor 3; FREAC-3; FOXC1; FKHL7; FREAC3]

[forkhead box protein C1; Forkhead box protein C1; forkhead box protein C1; forkhead box C1; Forkhead-related protein FKHL7; Forkhead-related transcription factor 3; FREAC-3]

[FOXC1]

[FOXC1; FOXC1; ARA; IGDA; IHG1; FKHL7; IRID1; RIEG3; FREAC3; FREAC-3; FKHL7; FREAC3; FREAC-3]

FOXC1_HUMAN

Polyclonal

IgG

Rabbit

Human

>95%, Protein G purified

Liquid

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

ELISA (EIA)

Immunogen: Recombinant Human Forkhead box protein C1 protein (1-79AA). Storage Buffer: Preservative: 0.03% Proclin 300. Constituents: 50% Glycerol, 0.01M PBS, PH 7.4. Conjugate: FITC. Species: Human. Research Area: Epigenetics and Nuclear Signaling

Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-21394 / sc-21396

Binding of FREAC-3 and FREAC-4 to their cognate sites results in bending of the DNA at an angle of 80-90 degrees. Regulates FOXO1 through binding to a conserved element, 5'-GTAAACAAA-3' in its promoter region, implicating FOXC1 as an important regulator of cell viability and resistance to oxidative stress in the eye.

119395716

NP_001444.2

NM_001453.2

Q12948

Heart Development Pathway (198802); Mesodermal Commitment Pathway (1458216)

This gene belongs to the forkhead family of transcription factors which is characterized by a distinct DNA-binding forkhead domain. The specific function of this gene has not yet been determined; however, it has been shown to play a role in the regulation of embryonic and ocular development. Mutations in this gene cause various glaucoma phenotypes including primary congenital glaucoma, autosomal dominant iridogoniodysgenesis anomaly, and Axenfeld-Rieger anomaly. [provided by RefSeq, Jul 2008]

FOXC1: Binding of FREAC-3 and FREAC-4 to their cognate sites results in bending of the DNA at an angle of 80-90 degrees. Monomer. Expressed in all tissues and cell lines examined. Protein type: Cell cycle regulation; Cell development/differentiation; DNA-binding; Transcription factor. Chromosomal Location of Human Ortholog: 6p25. Cellular Component: cytoplasm; nuclear heterochromatin; nucleoplasm; nucleus. Molecular Function: DNA bending activity; DNA binding; protein binding; sequence-specific DNA binding; transcription factor activity; transcription factor binding. Biological Process: cell migration; cell proliferation; eye development; heart development; mesenchymal cell development; negative regulation of angiogenesis; negative regulation of mitotic cell cycle; odontogenesis of dentine-containing teeth; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of transcription, DNA-dependent. Disease: Axenfeld-rieger Syndrome, Type 3; Iridogoniodysgenesis, Type 1

0.05 mg

160 USD

0.1 mg

235