ATP1A3 Antibody, Biotin conjugated | MyBioSource MBS7049718 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

ATP1A3 Antibody, Biotin conjugated

catalog :

MBS7049718

quantity :

0.05 mg

price :

160 USD

clonality :

polyclonal

host :

rabbit

conjugate :

biotin

reactivity :

human

application :

ELISA, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS7049718

products type :

Antibody

products full name :

ATP1A3 Antibody, Biotin conjugated

products short name :

[ATP1A3]

products name syn :

[Sodium/potassium-transporting ATPase subunit alpha-3; Na(+)/K(+)ATPase alpha-3 subunit; Na(+)/K(+) ATPase alpha(III) subunit; Sodium pump subunit alpha-3; ATP1A3]

other names :

[sodium/potassium-transporting ATPase subunit alpha-3 isoform 2; Sodium/potassium-transporting ATPase subunit alpha-3; sodium/potassium-transporting ATPase subunit alpha-3; ATPase Na+/K+ transporting subunit alpha 3; Na(+)/K(+) ATPase alpha(III) subunit; Sodium pump subunit alpha-3]

products gene name :

[ATP1A3]

other gene names :

[ATP1A3; ATP1A3; RDP; AHC2; CAPOS; DYT12; ATP1A1; Na(+)/K(+) ATPase alpha-3 subunit]

uniprot entry name :

AT1A3_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human

purity :

>95%, Protein G purified

form :

Liquid

storage stability :

Upon receipt, aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

tested application :

ELISA (EIA)

other info1 :

Immunogen: Recombinant Human Sodium/potassium-transporting ATPase subunit alpha-3 protein (143-278AA)

other info2 :

Storage Buffer: Preservative: 0.03% Proclin 300. Constituents: 50% Glycerol, 0.01M PBS, pH 7.4. Conjugation: Biotin. Species: Homo sapiens (Human). Research Area: Neuroscience. Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-134969 / sc-16052 / sc-67697

products description :

This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.

ncbi gi num :

371940938

ncbi acc num :

NP_001243142.1

ncbi gb acc num :

NM_001256213.1

uniprot acc num :

P13637

ncbi pathways :

Adrenergic Signaling In Cardiomyocytes Pathway (908257); Adrenergic Signaling In Cardiomyocytes Pathway (909696); Aldosterone-regulated Sodium Reabsorption Pathway (130626); Aldosterone-regulated Sodium Reabsorption Pathway (130590); Bile Secretion Pathway (193146); Bile Secretion Pathway (193095); Carbohydrate Digestion And Absorption Pathway (170720); Carbohydrate Digestion And Absorption Pathway (170654); Cardiac Conduction Pathway (1339115); Cardiac Muscle Contraction Pathway (93344)

ncbi summary :

The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 3 subunit. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

uniprot summary :

ATP1A3: This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. Defects in ATP1A3 are the cause of dystonia type 12 (DYT12); also known as rapid-onset dystonia parkinsonism (RDP). DYT12 is an autosomal dominant dystonia- parkinsonism disorder. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. DYT12 patients develop dystonia and parkinsonism between 15 and 45 years of age. The disease is characterized by an unusually rapid evolution of signs and symptoms. The sudden onset of symptoms over hours to a few weeks, often associated with physical or emotional stress, suggests a trigger initiating a nervous system insult resulting in permanent neurologic disability. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily. Protein type: EC 3.6.3.9; Endoplasmic reticulum; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel. Chromosomal Location of Human Ortholog: 19q13.31. Cellular Component: endoplasmic reticulum; Golgi apparatus; plasma membrane; sodium:potassium-exchanging ATPase complex; synapse. Molecular Function: chaperone binding; sodium:potassium-exchanging ATPase activity. Biological Process: ATP hydrolysis coupled proton transport; cellular potassium ion homeostasis; cellular sodium ion homeostasis; potassium ion import. Disease: Alternating Hemiplegia Of Childhood 2; Cerebellar Ataxia, Areflexia, Pes Cavus, Optic Atrophy, And Sensorineural Hearing Loss; Dystonia 12

size1 :

0.05 mg

price1 :

160 USD

size2 :

0.1 mg

price2 :

235

more info or order :

MyBioSource product webpage