Human fibroblast growth factor-23, FGF-23 ELISA Kit | MyBioSource MBS704928 product information

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Human fibroblast growth factor-23, FGF-23 ELISA Kit

catalog :

MBS704928

quantity :

48-Strip-Wells

price :

605 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS704928

products type :

ELISA Kit

products full name :

Human fibroblast growth factor-23, FGF-23 ELISA Kit

products short name :

fibroblast growth factor 23

products name syn :

Human fibroblast growth factor-23; FGF-23 ELISA Kit; ADHR; HPDR2; HYPF; PHPTC; tumor-derived hypophosphatemia inducing factor; fibroblast growth factor 23

other names :

fibroblast growth factor 23; Fibroblast growth factor 23; fibroblast growth factor 23; phosphatonin; tumor-derived hypophosphatemia inducing factor; fibroblast growth factor 23; Phosphatonin; Tumor-derived hypophosphatemia-inducing factorCleaved into the following 2 chains:Fibroblast growth factor 23 N-terminal peptide; Fibroblast growth factor 23 C-terminal peptide

products gene name :

FGF23

other gene names :

FGF23; FGF23; ADHR; FGFN; HYPF; HPDR2; PHPTC; HYPF; UNQ3027/PRO9828; FGF-23

uniprot entry name :

FGF23_HUMAN

reactivity :

Human

sequence length :

251

specificity :

This assay has high sensitivity and excellent specificity for detection of human FGF-23. No significant cross-reactivity or interference between human FGF-23 and analogues was observed.

storage stability :

Unopened test kits should be stored at 2 to 8 degree C upon receipt. Please refer to pdf manual for further storage instructions.

other info1 :

Samples: Serum, urine, cell culture supernates, tissue homogenates. Assay Type: Sandwich. Detection Range: 3.12 pg/ml -200 pg/ml. Sensitivity: 0.78 pg/ml.

other info2 :

Intra-assay Precision: Intra-assay Precision (Precision within an assay): CV%<8%. Three samples of known concentration were tested twenty times on one plate to assess. Inter-assay Precision: Inter-assay Precision (Precision between assays): CV%<10%. Three samples of known concentration were tested in twenty assays to assess.

products description :

Principle of the Assay This assay employs the quantitative sandwich enzyme immunoassay technique. Antibody specific for FGF-23 has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and any FGF-23 present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for FGF-23 is added to the wells. After washing, avidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of FGF-23 bound in the initial step. The color development is stopped and the intensity of the color is measured.

ncbi gi num :

10190674

ncbi acc num :

NP_065689.1

ncbi gb acc num :

NM_020638.2

uniprot acc num :

Q9GZV9

ncbi mol weight :

27,954 Da

ncbi pathways :

Activated Point Mutants Of FGFR2 Pathway (645281); Adaptive Immune System Pathway (366160); Constitutive PI3K/AKT Signaling In Cancer Pathway (685535); DAP12 Interactions Pathway (685549); DAP12 Signaling Pathway (685550); Disease Pathway (530764); Downstream Signal Transduction Pathway (106385); Downstream Signaling Events Of B Cell Receptor (BCR) Pathway (576250); Downstream Signaling Of Activated FGFR Pathway (160957); FGF Signaling Pathway (137989)

ncbi summary :

This gene encodes a member of the fibroblast growth factor family of proteins, which possess broad mitogenic and cell survival activities and are involved in a variety of biological processes. The product of this gene regulates phosphate homeostasis and transport in the kidney. The full-length, functional protein may be deactivated via cleavage into N-terminal and C-terminal chains. Mutation of this cleavage site causes autosomal dominant hypophosphatemic rickets (ADHR). Mutations in this gene are also associated with hyperphosphatemic familial tumoral calcinosis (HFTC). [provided by RefSeq, Feb 2013]

uniprot summary :

Function: Regulator of phosphate homeostasis. Inhibits renal tubular phosphate transport by reducing SLC34A1 levels. Upregulates EGR1 expression in the presence of KL Acts directly on the parathyroid to decrease PTH secretion Regulator of vitamin-D metabolism. Negatively regulates osteoblast differentiation and matrix mineralization.5 PublicationsManual assertion based on experiment in:Ref.2

size1 :

48-Strip-Wells

price1 :

605 USD

size2 :

96-Strip-Wells

price2 :

870

size3 :

5x96-Strip-Wells

price3 :

2950

size4 :

10x96-Strip-Wells

price4 :

5535

more info or order :

MyBioSource product webpage