catalog number :
MBS7049252
products full name :
TECPR2 Antibody
products short name :
[TECPR2]
products name syn :
[Tectonin beta-propeller repeat-containing protein 2; WD repeat-containing protein KIAA0329/KIAA0297; TECPR2; KIAA0297; KIAA0329]
other names :
[tectonin beta-propeller repeat-containing protein 2 isoform 2; Tectonin beta-propeller repeat-containing protein 2; tectonin beta-propeller repeat-containing protein 2; tectonin beta-propeller repeat containing 2; WD repeat-containing protein KIAA0329/KIAA0297]
products gene name :
[TECPR2]
other gene names :
[TECPR2; TECPR2; SPG49; KIAA0329; KIAA0297; KIAA0329]
uniprot entry name :
TCPR2_HUMAN
purity :
>95%, Protein G purified
storage stability :
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
tested application :
ELISA (EIA), Immunohistochemistry (IHC), Immunofluorescence (IF)
app notes :
IHC: 1: 20-1: 200. IF: 1: 50-1: 200
image1 heading :
Immunohistochemistry (IHC)
image2 heading :
Immunofluorescence (IF)
other info1 :
Immunogen: Recombinant Human Tectonin beta-propeller repeat-containing protein 2 protein (516-783AA)
other info2 :
Preservative: 0.03% Proclin 300. Constituents: 50% Glycerol, 0.01M PBS, PH 7.4. Conjugation: Non-conjugated
products description :
Probably plays a role as positive regulator of autophagy.
ncbi acc num :
NP_001166102.1
ncbi gb acc num :
NM_001172631.2
ncbi summary :
The protein encoded by this gene is a member of the tectonin beta-propeller repeat-containing (TECPR) family, and contains both TECPR and tryptophan-aspartic acid repeat (WD repeat) domains. This gene has been implicated in autophagy, as reduced expression levels of this gene have been associated with impaired autophagy. Recessive mutations in this gene have been associated with a hereditary form of spastic paraparesis (HSP). HSP is characterized by progressive spasticity and paralysis of the legs. There is also some evidence linking mutations in this gene with birdshot chorioretinopathy (BSCR), which results in inflammation of the choroid and retina. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015]
uniprot summary :
TECPR2: Belongs to the WD repeat KIAA0329 family. Protein type: Unknown function. Chromosomal Location of Human Ortholog: 14q32.31. Molecular Function: protein binding. Disease: Spastic Paraplegia 49, Autosomal Recessive