product summary
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company name :
MyBioSource
product type :
antibody
product name :
SPDEF Antibody
catalog :
MBS7049204
quantity :
0.05 mg
price :
160 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human, mouse
application :
western blot, ELISA, immunohistochemistry, enzyme immunoassay
more info or order :
image
image 1 :
Western Blot. Positive WB detected in: Mouse brain tissue. All lanes: SPDEF antibody at 3ug/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 38,36 kDa. Observed band size: 38 kDa.
image 2 :
Immunohistochemistry of paraffin-embedded human colon cancer using MBS7049204 at dilution of 1:100
image 3 :
Immunohistochemistry of paraffin-embedded human prostate cancer using MBS7049204 at dilution of 1:100
product information
catalog number :
MBS7049204
products type :
Antibody
products full name :
SPDEF Antibody
products short name :
[SPDEF]
products name syn :
[SAM pointed domain-containing Ets transcription factor; Prostate epithelium-specific Ets transcription factor; Prostate-specific Ets; Prostate-derived Ets factor; SPDEF; PDEF; PSE]
other names :
[SAM pointed domain-containing Ets transcription factor isoform 2; SAM pointed domain-containing Ets transcription factor; SAM pointed domain-containing Ets transcription factor; SAM pointed domain containing ETS transcription factor; Prostate epithelium-specific Ets transcription factor; Prostate-specific Ets; Prostate-derived Ets factor]
products gene name :
[SPDEF]
other gene names :
[SPDEF; SPDEF; PDEF; bA375E1.3; PDEF; PSE; Prostate-specific Ets]
uniprot entry name :
SPDEF_HUMAN
clonality :
Polyclonal
isotype :
IgG
host :
Rabbit
reactivity :
Human, Mouse
sequence length :
319
purity :
>95%, Protein G purified
form :
Liquid
storage stability :
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
tested application :
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
app notes :
WB: 1: 1000-1: 5000. IHC: 1: 20-1: 200
image1 heading :
Western Blot (WB)
image2 heading :
Immunohistochemistry (IHC)
image3 heading :
Immunohistochemistry (IHC)
other info1 :
Immunogen: Recombinant human SAM pointed domain-containing Ets transcription factor protein (145-247AA). Storage Buffer: Preservative: 0.03% Proclin 300. Constituents: 50% Glycerol, 0.01M PBS, PH 7.4. Conjugate: Non-conjugated. Research Area: Epigenetics and Nuclear Signaling. Species: Human
other info2 :
Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-46446 / sc-46445 / sc-46443 / sc-67022
products description :
May function as an androgen-independent transactivator of the prostate-specific antigen (PSA) promoter. Binds to 5'-GGAT-3' DNA sequences. May play a role in the regulation of the prostate gland and/or prostate cancer development. Acts as a transcriptional activator for SERPINB5 promoter.
ncbi gi num :
356582513
ncbi acc num :
NP_001239223.1
ncbi gb acc num :
NM_001252294.1
uniprot acc num :
O95238
ncbi pathways :
Regulation Of Androgen Receptor Activity Pathway (138027)
ncbi summary :
The protein encoded by this gene belongs to the ETS family of transcription factors. It is highly expressed in the prostate epithelial cells, and functions as an androgen-independent transactivator of prostate-specific antigen (PSA) promoter. Higher expression of this protein has also been reported in brain, breast, lung and ovarian tumors, compared to the corresponding normal tissues, and it shows better tumor-association than other cancer-associated molecules, making it a more suitable target for developing specific cancer therapies. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
uniprot summary :
SPDEF: May function as an androgen-independent transactivator of the prostate-specific antigen (PSA) promoter. Binds to 5'-GGAT- 3' DNA sequences. May play a role in the regulation of the prostate gland and/or prostate cancer development. Acts as a transcriptional activator for SERPINB5 promoter. Belongs to the ETS family. Protein type: DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor. Chromosomal Location of Human Ortholog: 6p21.3. Cellular Component: nucleus. Biological Process: cell differentiation; multicellular organismal development; negative regulation of transcription from RNA polymerase II promoter; positive regulation of apoptosis
size1 :
0.05 mg
price1 :
160 USD
size2 :
0.1 mg
price2 :
235
more info or order :
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.
"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."
Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...
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