MX1 Antibody | MyBioSource MBS7048712 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

MX1 Antibody

catalog :

MBS7048712

quantity :

0.05 mg

price :

160 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, enzyme immunoassay

more info or order :

MyBioSource product webpage

image

image 1 :

Western Blot. Positive WB detected in:A549 whole cell lysate,NIH/3T3 whole cell lysate,Hela whole cell lysate. All lanes: MX1 antibody at 3ug/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 76,56 kDa. Observed band size: 76 kDa.

image 2 :

Immunohistochemistry of paraffin-embedded human pancreatic tissue using MBS7048712 at dilution of 1:100

image 3 :

Immunofluorescent analysis of PC3 cells using MBS7048712 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

product information

catalog number :

MBS7048712

products type :

Antibody

products full name :

MX1 Antibody

products short name :

[MX1]

products name syn :

[Interferon-induced GTP-binding protein Mx1; Interferon-induced protein p78; IFI-78K; Interferon-regulated resistance GTP-binding protein MxA; Myxoma resistance pr; MX1]

other names :

[interferon-induced GTP-binding protein Mx1 isoform a; Interferon-induced GTP-binding protein Mx1; interferon-induced GTP-binding protein Mx1; MX dynamin like GTPase 1; Interferon-induced protein p78; IFI-78K]

products gene name :

[MX1]

other gene names :

[MX1; MX1; MX; MxA; IFI78; IFI-78K; IFI-78K]

uniprot entry name :

MX1_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

sequence length :

662

purity :

>95%, Protein G purified

form :

Liquid

storage stability :

Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

tested application :

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)

app notes :

WB: 1: 1000-1: 5000. IHC: 1: 20-1: 200. IF: 1: 50-1: 200. IP: 1: 200-1: 2000

image1 heading :

Western Blot (WB)

image2 heading :

Immunohistochemistry (IHC)

image3 heading :

Immunohistochemistry (IHC)

image4 heading :

Immunoprecipitation (IP)

image4 description :

Immunoprecipitating MX1 in Hela whole cell lysate. Lane 1: Rabbit monoclonal IgG(1ug)instead of MBS7048712 in Hela whole cell lysate. For western blotting, a HRP-conjugated light chain specific antibody was used as the Secondary antibody (1/50000). Lane 2: MBS7048712(4ug)+ Hela whole cell lysate(500ug). Lane 3: Hela whole cell lysate (20ug).

other info1 :

Immunogen: Recombinant Human Interferon-induced GTP-binding protein Mx1 protein (7-172AA)

other info2 :

Preservative: 0.03% Proclin 300. Constituents: 50% Glycerol, 0.01M PBS, PH 7.4. Conjugation: Non-conjugated. Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-34128 / sc-34130 / sc-34131 / sc-50509

products description :

Interferon-induced dynamin-like GTPase with antiviral activity against a wide range of RNA viruses and some DNA viruses. Its target viruses include negative-stranded RNA viruses and HBV through binding and inactivation of their ribonucleocapsid. May also antagonize reoviridae and asfarviridae replication. Inhibits thogoto virus (THOV) replication by preventing the nuclear import of viral nucleocapsids. Inhibits La Crosse virus (LACV) replication by sequestering viral nucleoprotein in perinuclear complexes, preventing genome amplification, budding, and egress. Inhibits influenza A virus (IAV) replication by decreasing or delaying NP synthesis and by blocking endocytic traffic of incoming virus particles. Enhances ER stress-mediated cell death after influenza virus infection. May regulate the calcium channel activity of TRPCs.

ncbi gi num :

222136619

ncbi acc num :

NP_001138397.1

ncbi gb acc num :

NM_001144925.2

uniprot acc num :

P20591

ncbi pathways :

Antiviral Mechanism By IFN-stimulated Genes Pathway (1269316); Cytokine Signaling In Immune System Pathway (1269310); ISG15 Antiviral Mechanism Pathway (1269317); Immune System Pathway (1269170); Influenza A Pathway (217173); Influenza A Pathway (217150); Interferon Signaling Pathway (1269311); Interferon Alpha/beta Signaling Pathway (1269312); Measles Pathway (213306); Measles Pathway (213277)

ncbi summary :

This gene encodes a guanosine triphosphate (GTP)-metabolizing protein that participates in the cellular antiviral response. The encoded protein is induced by type I and type II interferons and antagonizes the replication process of several different RNA and DNA viruses. There is a related gene located adjacent to this gene on chromosome 21, and there are multiple pseudogenes located in a cluster on chromosome 4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

uniprot summary :

MX1: Dynamin-like GTPase acting as a cell-autonomous host restriction factor against many viral pathogens. Shows activity against influenza viruses, rhabdovirus VSV, bunyavirus LACV, Thogoto virus, measles virus, Hantaan virus, Coxsackie virus CVB, Rift Valley fever virus RVFV, hepatitis B virus HBV, and Crimean- Congo hemorrhagic fever virus CCHFV. Belongs to the dynamin family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Apoptosis; Hydrolase. Chromosomal Location of Human Ortholog: 21q22.3. Cellular Component: cytoplasm; cytosol; nuclear membrane; nucleus; perinuclear region of cytoplasm. Molecular Function: GTPase activity; microtubule binding; protein binding. Biological Process: apoptosis; defense response; defense response to virus; innate immune response; negative regulation of viral genome replication; organelle fission; response to virus; signal transduction

size1 :

0.05 mg

price1 :

160 USD

size2 :

0.1 mg

price2 :

235

more info or order :

MyBioSource product webpage