GCGR Antibody | MyBioSource MBS7048237 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

GCGR Antibody

catalog :

MBS7048237

quantity :

0.05 mg

price :

160 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

image

image 1 :

Western Blot. Positive WB detected in:Mouse heart tissue,Mouse lung tissue,Mouse kidney tissue. All lanes: Gcgr antibody at 3ug/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 55 kDa. Observed band size: 55 kDa.

image 2 :

Immunohistochemistry of paraffin-embedded human liver tissue using MBS7048237 at dilution of 1:100

image 3 :

Immunofluorescent analysis of HepG2 cells using MBS7048237 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

product information

catalog number :

MBS7048237

products type :

Antibody

products full name :

GCGR Antibody

products short name :

[GCGR]

products name syn :

[Glucagon receptorGL-R; GCGR]

other names :

[glucagon receptor; Glucagon receptor; glucagon receptor; glucagon receptor]

products gene name :

[GCGR]

other gene names :

[GCGR; GCGR; GGR; GL-R; GL-R]

uniprot entry name :

GLR_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human, Mouse

purity :

>95%, Protein G purified

form :

Liquid

storage stability :

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

tested application :

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

app notes :

WB: 1: 500-1: 5000. IHC: 1: 20-1: 200. IF: 1: 50-1: 200

image1 heading :

Western Blot (WB)

image2 heading :

Immunohistochemistry (IHC)

image3 heading :

Immunohistochemistry (IHC)

other info1 :

Immunogen: Recombinant Human Glucagon receptor protein (26-136AA). Research Area: Signal Transduction. Species: Human

other info2 :

Preservative: 0.03% Proclin 300. Constituents: 50% Glycerol, 0.01M PBS, PH 7.4. Conjugation: Non-conjugated. Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-34638 / sc-34640 / sc-34641 / sc-66912

products description :

G-protein coupled receptor for glucagon that plays a central role in the regulation of blood glucose levels and glucose homeostasis. Regulates the rate of hepatic glucose production by promoting glycogen hydrolysis and gluconeogenesis. Plays an important role in mediating the responses to fasting. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Promotes activation of adenylate cyclase. Besides, plays a role in signaling via a phosphatidylinositol-calcium second messenger system.

ncbi gi num :

4503947

ncbi acc num :

NP_000151.1

ncbi gb acc num :

NM_000160.4

uniprot acc num :

P47871

ncbi pathways :

Class B/2 (Secretin Family Receptors) Pathway (1269570); G Alpha (q) Signalling Events Pathway (1269578); G Alpha (s) Signalling Events Pathway (1269575); GPCR Downstream Signaling Pathway (1269574); GPCR Ligand Binding Pathway (1269544); GPCRs, Class B Secretin-like Pathway (198781); Gastrin-CREB Signalling Pathway Via PKC And MAPK (1269592); Glucagon Signaling In Metabolic Regulation Pathway (1270108); Glucagon Signaling Pathway (1144996); Glucagon Signaling Pathway (1158201)

ncbi summary :

The protein encoded by this gene is a glucagon receptor that is important in controlling blood glucose levels. Defects in this gene are a cause of non-insulin-dependent diabetes mellitus (NIDDM).[provided by RefSeq, Jan 2010]

uniprot summary :

GCGR: This is a receptor for glucagon which plays a central role in regulating the level of blood glucose by controlling the rate of hepatic glucose production and insulin secretion. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system. Belongs to the G-protein coupled receptor 2 family. Protein type: GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR. Chromosomal Location of Human Ortholog: 17q25. Cellular Component: integral to membrane; integral to plasma membrane; plasma membrane. Molecular Function: glucagon receptor activity; guanyl-nucleotide exchange factor activity. Biological Process: G-protein signaling, coupled to cAMP nucleotide second messenger; generation of precursor metabolites and energy; glucose homeostasis; regulation of blood pressure; response to nutrient; response to starvation. Disease: Diabetes Mellitus, Noninsulin-dependent

size1 :

0.05 mg

price1 :

160 USD

size2 :

0.1 mg

price2 :

235

more info or order :

MyBioSource product webpage