catalog number :
MBS7048101
products full name :
EN2 Antibody
products short name :
[EN2]
products name syn :
[Homeobox protein engrailed-2; Homeobox protein en-2; Hu-En-2; EN2]
other names :
[homeobox protein engrailed-2; Homeobox protein engrailed-2; homeobox protein engrailed-2; engrailed homeobox 2]
products gene name :
[EN2]
other gene names :
[EN2; EN2; Homeobox protein en-2; Hu-En-2]
uniprot entry name :
HME2_HUMAN
purity :
>95%, Protein G purified
storage stability :
Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
tested application :
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
app notes :
WB: 1: 500-1: 5000. IHC: 1: 20-1: 200. IF: 1: 50-1: 200
image1 heading :
Western Blot (WB)
image2 heading :
Immunohistochemistry (IHC)
image3 heading :
Immunohistochemistry (IHC)
other info1 :
Immunogen: Recombinant Human Homeobox protein engrailed-2 protein (1-251AA). Research Area: Neuroscience. Target: EN2
other info2 :
Preservative: 0.03% Proclin 300. Constituents: 50% Glycerol, 0.01M PBS, pH 7.4. Conjugation: Non-conjugated. Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-133549 / sc-46105 / sc-66877 / sc-66878 / sc-8111
products description :
nucleus, multicellular organism development
ncbi acc num :
NP_001418.2
ncbi gb acc num :
NM_001427.3
ncbi pathways :
Dopaminergic Neurogenesis Pathway (1458255)
ncbi summary :
Homeobox-containing genes are thought to have a role in controlling development. In Drosophila, the 'engrailed' (en) gene plays an important role during development in segmentation, where it is required for the formation of posterior compartments. Different mutations in the mouse homologs, En1 and En2, produced different developmental defects that frequently are lethal. The human engrailed homologs 1 and 2 encode homeodomain-containing proteins and have been implicated in the control of pattern formation during development of the central nervous system. [provided by RefSeq, Jul 2008]
uniprot summary :
En-2: Genetic variations in EN2 may be associated with susceptibility to autism. Belongs to the engrailed homeobox family. Protein type: DNA-binding; Transcription factor. Chromosomal Location of Human Ortholog: 7q36. Cellular Component: nucleus. Biological Process: multicellular organismal development. Disease: Autism, Susceptibility To, 10