IFNLR1 Antibody | MyBioSource MBS7045831 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

IFNLR1 Antibody

catalog :

MBS7045831

quantity :

0.05 mL

price :

120 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, ELISA, immunohistochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

image

image 1 :

Western blot. All lanes: IFNLR1antibody at 3.04ug/ml. Lane 1: Mouse kidney tissue. Lane 2: Mouse liver tissue. Lane 3: Human placenta tissue. Lane 4: Mouse lung tissue. Lane 5: Jurkat whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 58,55,24,28 kDa. Observed band size: 58 kDa.

image 2 :

Immunohistochemistry of paraffin-embedded human testis tissue MBS7045831 at dilution 1:100

image 3 :

Immunohistochemistry of paraffin-embedded human adrenal gland tissue MBS7045831 at dilution 1:100

product information

catalog number :

MBS7045831

products type :

Antibody

products full name :

IFNLR1 Antibody

products short name :

[IFNLR1]

products name syn :

[Interferon lambda receptor 1; IFN-lambda receptor 1; IFN-lambda-R1; Cytokine receptor class-II member 12; Cytokine receptor family 2 member 12; CRF2-12; Interleukin-28 receptor subunit alpha; IL-28 receptor subunit alpha; IL-28R-alpha; IL-28RA; Likely interleukin or cytokine receptor 2; LICR2; IFNLR1; IL28RA; LICR2]

other names :

[interferon lambda receptor 1 isoform 1; Interferon lambda receptor 1; interferon lambda receptor 1; interferon lambda receptor 1; Cytokine receptor class-II member 12; Cytokine receptor family 2 member 12; CRF2-12; Interleukin-28 receptor subunit alpha; IL-28 receptor subunit alpha; IL-28R-alpha; IL-28RA; Likely interleukin or cytokine receptor 2; LICR2]

products gene name :

[IFNLR1]

other gene names :

[IFNLR1; IFNLR1; IFNLR; LICR2; IL28RA; CRF2/12; IL-28R1; IL28RA; LICR2; IFN-lambda receptor 1; IFN-lambda-R1; CRF2-12; IL-28 receptor subunit alpha; IL-28R-alpha; IL-28RA; LICR2]

uniprot entry name :

INLR1_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human, Mouse

sequence length :

520

purity :

Antigen Affinity Purified

form :

Liquid

storage stability :

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

tested application :

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

app notes :

WB 1:1000-1:5000. IHC 1:20-1:200

image1 heading :

Western Blot (WB)

image2 heading :

Immunohistochemistry (IHC)

image3 heading :

Immunohistochemistry (IHC)

other info1 :

Species: Human. Immunogen: Recombinant human Interferon lambda receptor 1 protein (21-228AA). Research Area: Immunology. Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

other info2 :

Conjugate: Non-conjugated. Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-66541 / sc-66542 / sc-135101

products description :

The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state. Determines the cell type specificity of the lambda interferon action. Shows a more restricted pattern of expression in the epithelial tissues thereby limiting responses to lambda interferons primarily to epithelial cells of the respiratory, gastrointestinal, and reproductive tracts. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium.

ncbi gi num :

25014103

ncbi acc num :

NP_734464.1

ncbi gb acc num :

NM_170743.3

uniprot acc num :

Q8IU57

ncbi pathways :

Cytokine Signaling In Immune System Pathway (1269310); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); Immune System Pathway (1269170); Jak-STAT Signaling Pathway (83077); Jak-STAT Signaling Pathway (488); Signaling By Interleukins Pathway (1269318); Type III Interferon Signaling Pathway (755437)

ncbi summary :

The protein encoded by this gene belongs to the class II cytokine receptor family. This protein forms a receptor complex with interleukine 10 receptor, beta (IL10RB). The receptor complex has been shown to interact with three closely related cytokines, including interleukin 28A (IL28A), interleukin 28B (IL28B), and interleukin 29 (IL29). The expression of all three cytokines can be induced by viral infection. The cells overexpressing this protein have been found to have enhanced responses to IL28A and IL29, but decreased response to IL28B. Three alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

uniprot summary :

IL28RA: The IL28RA/IL10RB dimer is a receptor for IL28A, IL28B and IL29. The ligand/receptor complex seems to signal through the Jak-STAT pathway. Belongs to the type II cytokine receptor family. 4 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral. Chromosomal Location of Human Ortholog: 1p36.11. Cellular Component: interleukin-28 receptor complex; plasma membrane. Molecular Function: hematopoietin/interferon-class (D200-domain) cytokine receptor activity; protein binding. Biological Process: cytokine and chemokine mediated signaling pathway; defense response to virus; mucosal immune response; regulation of defense response to virus by host

size1 :

0.05 mL

price1 :

120 USD

size2 :

0.1 mL

price2 :

160

more info or order :

MyBioSource product webpage