product summary
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company name :
MyBioSource
product type :
antibody
product name :
TMEM64 Antibody
catalog :
MBS7044965
quantity :
0.05 mg
price :
160 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human, mouse
application :
western blot, ELISA, immunohistochemistry, enzyme immunoassay
more info or order :
image
image 1 :
Western blot. All lanes: TMEM64 antibody IgG at 8ug/ml+ Mouse brain tissue. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 40,13,15,34 kDa. Observed band size: 40 kDa.
image 2 :
Immunohistochemistry of paraffin-embedded human lung tissue using MBS7044965 at dilution of 1:100
product information
catalog number :
MBS7044965
products type :
Antibody
products full name :
TMEM64 Antibody
products short name :
[TMEM64]
products name syn :
[Transmembrane protein 64; TMEM64]
other names :
[transmembrane protein 64 isoform 1; Transmembrane protein 64; transmembrane protein 64; transmembrane protein 64]
products gene name :
[TMEM64]
other gene names :
[TMEM64; TMEM64]
uniprot entry name :
TMM64_HUMAN
clonality :
Polyclonal
isotype :
IgG
host :
Rabbit
reactivity :
Human, Mouse
sequence length :
380
purity :
>95%, Protein G purified
form :
Liquid
storage stability :
Upon receipt store -20°C or -80°C. Avoid repeated freeze.
tested application :
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
app notes :
WB: 1:1000-1:5000. IHC 1:20-1:200
image1 heading :
Western Blot (WB)
image2 heading :
Immunohistochemistry (IHC)
other info1 :
Species: Human. Immunogen: Recombinant human Transmembrane protein 64 protein (40-118AA).
other info2 :
Conjugate: Non-conjugated. Buffer: Preservative: 0.03% Proclin 300. Constituents: 50% Glycerol, 0.01M PBS, PH 7.4. Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-87460 / sc-87462
products description :
Positively regulates TNFSF11-induced osteoclast differentiation. Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with SERCA2 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytosolic Ca (2+) spiking for activation of NFATC1 and production of mitochondrial ROS, thereby triggering Ca (2+) signaling cascades that promote osteoclast differentiation and activation. Negatively regulates osteoblast differentiation and positively regulates adipocyte differentiation via modulation of the canonical Wnt signaling pathway. Mediates the switch in lineage commitment to osteogenesis rather than to adipogenesis in mesenchymal stem cells by negatively regulating the expression, activity and nuclear localization of CTNNB1.
ncbi gi num :
223555958
ncbi acc num :
NP_001008495.2
ncbi gb acc num :
NM_001008495.3
uniprot acc num :
Q6YI46
uniprot summary :
TMEM64: Belongs to the TVP38/TMEM64 family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, multi-pass; Membrane protein, integral. Chromosomal Location of Human Ortholog: 8q21.3. Biological Process: negative regulation of osteoblast differentiation; positive regulation of fat cell differentiation
size1 :
0.05 mg
price1 :
160 USD
size2 :
0.1 mg
price2 :
235
more info or order :
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.
"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."
Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...
"MyBioSource offers the best products at unbeatable prices."
Please spend a few minutes to browse our online catalogs and see the wide range of products available. We ship our products through our shipping/distribution facility in San Diego, California, USA.
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