product summary
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company name :
MyBioSource
product type :
antibody
product name :
DUOX2 Antibody
catalog :
MBS7043779
quantity :
0.05 mL
price :
120 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human, mouse
application :
western blot, ELISA, immunohistochemistry, enzyme immunoassay
more info or order :
image
image 1 :
Western blot. All lanes: DUOX2 antibody at 2.18ug/ml. Lane 1: Mouse lung tissue. Lane 2: A549 whole cell lysate. Lane 3: CEM whole cell lysate. Lane 4: 293T whole cell lysate. Lane 5: Jurkat whole cell lysate. Lane 6: HepG-2 whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 175 kDa. Observed band size: 175 kDa.
image 2 :
Immunohistochemistry of paraffin-embedded human small intestine using MBS7043779 at dilution 1:100
product information
catalog number :
MBS7043779
products type :
Antibody
products full name :
DUOX2 Antibody
products short name :
[DUOX2]
products name syn :
[Dual oxidase 2; Large NOX 2; Long NOX 2; NADH/NADPH thyroid oxidase p138-tox; NADPH oxidase/peroxidase DUOX2; NADPH thyroid oxidase 2; Thyroid oxidase 2; p138 thyroid oxidase; DUOX2; LNOX2; THOX2]
other names :
[dual oxidase 2; Dual oxidase 2; dual oxidase 2; dual oxidase 2; Large NOX 2; Long NOX 2; NADH/NADPH thyroid oxidase p138-tox; NADPH oxidase/peroxidase DUOX2; NADPH thyroid oxidase 2; Thyroid oxidase 2; p138 thyroid oxidase]
products gene name :
[DUOX2]
other gene names :
[DUOX2; DUOX2; TDH6; LNOX2; THOX2; NOXEF2; P138-TOX; LNOX2; THOX2]
uniprot entry name :
DUOX2_HUMAN
clonality :
Polyclonal
isotype :
IgG
host :
Rabbit
reactivity :
Human, Mouse
sequence length :
1548
purity :
Antigen Affinity Purified
form :
Liquid
storage stability :
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
tested application :
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
image1 heading :
Western Blot (WB)
image2 heading :
Immunohistochemistry (IHC)
other info1 :
Species: Human. Immunogen: Recombinant human Dual oxidase 2 protein (N-100AA)
other info2 :
Conjugate: Non-conjugated. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-49938 / sc-49939
products description :
Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain.
ncbi gi num :
132566532
ncbi acc num :
NP_054799.4
ncbi gb acc num :
NM_014080.4
uniprot acc num :
Q9NRD8
ncbi mol weight :
175,364 Da
ncbi pathways :
Amine-derived Hormones Pathway (1270175); Metabolism Pathway (1269956); Metabolism Of Amino Acids And Derivatives Pathway (1270158); NOD Pathway (198792); Thyroid Hormone Synthesis Pathway (835410); Thyroid Hormone Synthesis Pathway (839541); Thyroxine Biosynthesis Pathway (1270177)
ncbi summary :
The protein encoded by this gene is a glycoprotein and a member of the NADPH oxidase family. The synthesis of thyroid hormone is catalyzed by a protein complex located at the apical membrane of thyroid follicular cells. This complex contains an iodide transporter, thyroperoxidase, and a peroxide generating system that includes this encoded protein and DUOX1. This protein is known as dual oxidase because it has both a peroxidase homology domain and a gp91phox domain. [provided by RefSeq, Jul 2008]
uniprot summary :
DUOX2: Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain. Defects in DUOX2 are a cause of thyroid dyshormonogenesis 6 (TDH6). A disorder due to a defective conversion of accumulated iodide to organically bound iodine. The iodide organification defect can be partial or complete. Protein type: EC 1.6.3.1; Membrane protein, integral; Membrane protein, multi-pass; Oxidoreductase. Chromosomal Location of Human Ortholog: 15q15.3. Cellular Component: plasma membrane. Molecular Function: calcium ion binding; NAD(P)H oxidase activity. Biological Process: cuticle development; cytokine and chemokine mediated signaling pathway; response to cAMP; response to virus; thyroid hormone generation. Disease: Thyroid Dyshormonogenesis 6
size1 :
0.05 mL
price1 :
120 USD
size2 :
0.1 mL
price2 :
160
more info or order :
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.
"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."
Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...
"MyBioSource offers the best products at unbeatable prices."
Please spend a few minutes to browse our online catalogs and see the wide range of products available. We ship our products through our shipping/distribution facility in San Diego, California, USA.
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