Human integrin beta2, ITG beta2/CD11+CD18 ELISA Kit | MyBioSource MBS704374 product information

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Human integrin beta2, ITG beta2/CD11+CD18 ELISA Kit

catalog :

MBS704374

quantity :

48-Strip-Wells

price :

510 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS704374

products type :

ELISA Kit

products full name :

Human integrin beta2, ITG beta2/CD11+CD18 ELISA Kit

products short name :

integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)

products name syn :

Human integrin beta2; ITG beta2/CD11+CD18 ELISA Kit; CD18; LAD; LCAMB; LFA-1; MAC-1; MF17; MFI7; OTTHUMP00000115279; OTTHUMP00000115281; OTTHUMP00000115282; cell surface adhesion glycoprotein LFA-1/CR3/P150; 959 beta subunit precursor) ; complement receptor; integrin; beta 2 (complement component 3 receptor 3 and 4 subunit)

other names :

integrin beta-2; Integrin beta-2; integrin beta-2; integrin beta chain, beta 2; complement receptor C3 beta-subunit; complement receptor C3 subunit beta; leukocyte cell adhesion molecule CD18; leukocyte-associated antigens CD18/11A, CD18/11B, CD18/11C; cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta; cell surface adhesion glycoprotein LFA-1/CR3/P150,959 beta subunit precursor); integrin, beta 2 (complement component 3 receptor 3 and 4 subunit); Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta; Complement receptor C3 subunit beta; CD_antigen: CD18

products gene name :

ITGB2

other gene names :

ITGB2; ITGB2; LAD; CD18; MF17; MFI7; LCAMB; LFA-1; MAC-1; CD18; MFI7

uniprot entry name :

ITB2_HUMAN

reactivity :

Human

sequence length :

769

specificity :

This assay has high sensitivity and excellent specificity for detection of Human ITGB2. No significant cross-reactivity or interference between Human ITGB2 and analogues was observed.

storage stability :

Unopened test kits should be stored at 2 to 8 degree C upon receipt. Please refer to pdf manual for further storage instructions.

other info1 :

Assay Type: Sandwich

other info2 :

Intra-assay Precision: Intra-assay Precision (Precision within an assay): CV% is less than 8%. Three samples of known concentration were tested twenty times on one plate to assess. Inter-assay Precision (Precision between assays): CV% is less than 10%. Three samples of known concentration were tested in twenty assays to assess. Detection Wavelength: 450 nm. Sample Volume: 50-100ul. Protein Biological Process 1: Cell Adhesion. Protein Biological Process 3: Cell adhesion

products description :

Principle of the Assay: This assay employs the quantitative sandwich enzyme immunoassay technique. Antibody specific for ITG beta2 has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and any ITG beta2 present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for ITG beta2 is added to the wells. After washing, avidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of ITG beta2 bound in the initial step. The color development is stopped and the intensity of the color is measured.

ncbi gi num :

89191865

ncbi acc num :

NP_000202.2

ncbi gb acc num :

NM_000211.3

uniprot acc num :

P05107

ncbi mol weight :

84,782 Da

ncbi pathways :

Adaptive Immune System Pathway (366160); Amoebiasis Pathway (167324); Amoebiasis Pathway (167191); CXCR3-mediated Signaling Events Pathway (138011); Cell Adhesion Molecules (CAMs) Pathway (83069); Cell Adhesion Molecules (CAMs) Pathway (480); Cell Surface Interactions At The Vascular Wall Pathway (106062); Extracellular Matrix Organization Pathway (576262); Focal Adhesion Pathway (198795); HIF-1-alpha Transcription Factor Network Pathway (138045)

ncbi summary :

The product of this gene belongs to the integrin beta chain family of proteins. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. This gene encodes the integrin beta chain beta 2. A given chain may combine with multiple partners resulting in different integrins. For example, beta 2 combines with the alpha L chain to form the integrin LFA-1, and combines with the alpha M chain to form the integrin Mac-1. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. Defects in this gene are the cause of leukocyte adhesion deficiency type I (LAD1). Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]

uniprot summary :

Function: Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrins alpha-M/beta-2 and alpha-X/beta-2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin alpha-X/beta-2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin alpha-M/beta-2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin alpha-M/beta-2 is also a receptor for factor X. Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1. Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation.1 PublicationManual assertion based on experiment in:Ref.15

size1 :

48-Strip-Wells

price1 :

510 USD

size2 :

96-Strip-Wells

price2 :

725

size3 :

5x96-Strip-Wells

price3 :

2565

size4 :

10x96-Strip-Wells

price4 :

4800

more info or order :

MyBioSource product webpage