ELISA/assay

Human asialoglyco protein receptor, ASGPR ELISA Kit

MBS703995

48-Strip-Wells

565 USD

ELISA Kit

Human asialoglyco protein receptor, ASGPR ELISA Kit

asialoglyco protein receptor, ASGPR

Human asialoglyco protein receptor; ASGPR ELISA Kit; ASGPR; CLEC4H1; Hs.12056; C-type lectin domain family 4; member H1; hepatic lectin H1; asialoglycoprotein receptor 1; ASGR1; asialoglyco protein receptor; ASGPR

asialoglycoprotein receptor 1 isoform b; Asialoglycoprotein receptor 1; asialoglycoprotein receptor 1; hepatic lectin H1; C-type lectin domain family 4 member H1; asialoglycoprotein receptor 1; C-type lectin domain family 4 member H1; Hepatic lectin H1; HL-1

ASGPR

ASGR1; ASGR1; HL-1; ASGPR; ASGPR1; CLEC4H1; CLEC4H1; ASGP-R 1; ASGPR 1; HL-1

ASGR1_HUMAN

Human

252

This assay has high sensitivity and excellent specificity for detection of Human ASGPR. No significant cross-reactivity or interference between Human ASGPR and analogues was observed.

Unopened test kits should be stored at 2 to 8 degree C upon receipt. Please refer to pdf manual for further storage instructions.

Samples: Serum, plasma, tissue homogenates. Assay Type: Sandwich. Detection Range: 31.2 ng/ml-2000 ng/ml. Sensitivity: 7.8 ng/ml

Intra-assay Precision: Intra-assay Precision (Precision within an assay): CV% is less than 8%. Three samples of known concentration were tested twenty times on one plate to assess. Inter-assay Precision (Precision between assays): CV% is less than 10%. Three samples of known concentration were tested in twenty assays to assess. Detection Wavelength: 450 nm. Sample Volume: 50-100ul

Principle of the Assay: This assay employs the quantitative sandwich enzyme immunoassay technique. Antibody specific for ASGPR has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and any ASGPR present is bound by the immobilized antibody. After removing any unbound substances, a Horseradish Peroxidase (HRP)-conjugated antibody specific for ASGPR is added to the wells. Following a wash to remove any unbound reagent, a substrate solution is added to the wells and color develops in proportion to the amount of ASGPR bound in the initial step. The color development is stopped and the intensity of the color is measured.

308387363

NP_001184145.1

NM_001197216.2

P07306

29,144 Da

Thyroid Hormone Synthesis Pathway (835410); Thyroid Hormone Synthesis Pathway (839541)

This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. The protein encoded by this gene is the more abundant major subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]

Function: Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface.

48-Strip-Wells

565 USD

96-Strip-Wells

810

5x96-Strip-Wells

2750

10x96-Strip-Wells

5150