Human Bone morphogenetic protein receptor II, BMPR-II ELISA Kit | MyBioSource MBS703759 product information

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Human Bone morphogenetic protein receptor II, BMPR-II ELISA Kit

catalog :

MBS703759

quantity :

48-Strip-Wells

price :

510 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS703759

products type :

ELISA Kit

products full name :

Human Bone morphogenetic protein receptor II, BMPR-II ELISA Kit

products short name :

bone morphogenetic protein receptor, type II (serine/threonine kinase)

products name syn :

Human Bone morphogenetic protein receptor II; BMPR-II ELISA Kit; BMPR-II; BMPR3; BMR2; BRK-3; FLJ41585; FLJ76945; PPH1; T-ALK; BMP type II receptor; bone morphogenetic protein receptor type II; bone morphogenetic protein receptor type-2; type II activin receptor-lik; bone morphogenetic protein receptor; type II (serine/threonine kinase)

other names :

bone morphogenetic protein receptor type-2; Bone morphogenetic protein receptor type-2; bone morphogenetic protein receptor type-2; BMPR-2; BMP type-2 receptor; BMP type II receptor; type II activin receptor-like kinase; bone morphogenetic protein receptor type II; type II receptor for bone morphogenetic protein-4; bone morphogenetic protein receptor, type II (serine/threonine kinase); Bone morphogenetic protein receptor type II; BMP type II receptor; BMPR-II

products gene name :

BMPR2

other gene names :

BMPR2; BMPR2; BMR2; PPH1; BMPR3; BRK-3; POVD1; T-ALK; BMPR-II; PPH1; BMP type-2 receptor; BMPR-2; BMP type II receptor; BMPR-II

uniprot entry name :

BMPR2_HUMAN

reactivity :

Human

sequence length :

1038

specificity :

This assay has high sensitivity and excellent specificity for detection of human BMPR-II. No significant cross-reactivity or interference between human BMPR-II and analogues was observed.

storage stability :

Unopened test kits should be stored at 2 to 8 degree C upon receipt. Please refer to pdf manual for further storage instructions.

other info1 :

Samples: Serum, plasma, tissue homogenates, cell lysates. Assay Type: Sandwich. Detection Range: 6.25 pg/ml -400 pg/ml. Sensitivity: 1.56 pg/ml.

other info2 :

Intra-assay Precision: Intra-assay Precision (Precision within an assay): CV%<8%. Three samples of known concentration were tested twenty times on one plate to assess. Inter-assay Precision: Inter-assay Precision (Precision between assays): CV%<10%. Three samples of known concentration were tested in twenty assays to assess.

products description :

Principle of the Assay This assay employs the quantitative sandwich enzyme immunoassay technique. Antibody specific for BMPR-II has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and any BMPR-II present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for BMPR-II is added to the wells. After washing, avidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of BMPR-II bound in the initial step. The color development is stopped and the intensity of the color is measured.

ncbi gi num :

15451916

ncbi acc num :

NP_001195.2

ncbi gb acc num :

NM_001204.6

uniprot acc num :

Q13873

ncbi mol weight :

115,201 Da

ncbi pathways :

ALK1 Signaling Events Pathway (137968); ALK2 Signaling Events Pathway (137983); BMP Receptor Signaling Pathway (137948); BMP Signalling And Regulation Pathway (198910); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); Heart Development Pathway (198802); Hippo Signaling Pathway (749777); Hippo Signaling Pathway (750388); Id Signaling Pathway (198871)

ncbi summary :

This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of two different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension, both familial and fenfluramine-associated, and with pulmonary venoocclusive disease. [provided by RefSeq, Jul 2008]

uniprot summary :

Function: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Binds to BMP-7, BMP-2 and, less efficiently, BMP-4. Binding is weak but enhanced by the presence of type I receptors for BMPs. Catalytic activity: ATP + [receptor-protein] = ADP + [receptor-protein] phosphate. Cofactor: Magnesium or manganese

size1 :

48-Strip-Wells

price1 :

510 USD

size2 :

96-Strip-Wells

price2 :

725

size3 :

5x96-Strip-Wells

price3 :

2565

size4 :

10x96-Strip-Wells

price4 :

4800

more info or order :

MyBioSource product webpage