ELISA/assay

Human hepcidin, Hepc ELISA Kit

MBS703695

48-Strip-Wells

565 USD

ELISA Kit

Human hepcidin, Hepc ELISA Kit

hepcidin antimicrobial peptide

Human hepcidin (Hepc) ELISA Kit; HEPC; HEPCIDIN; HFE2B; LEAP-1; LEAP1; PLTR; liver-expressed antimicrobial peptide; putative liver tumor regressor; hepcidin antimicrobial peptide

hepcidin preproprotein; Hepcidin; Liver-expressed antimicrobial peptide 1; LEAP-1; Putative liver tumor regressor; PLTR

HAMP

HAMP; HEPC; LEAP1; UNQ487/PRO1003; LEAP-1; PLTR; Hepc25; Hepc20

HEPC_HUMAN

Human

84

This assay has high sensitivity and excellent specificity for detection of Human HAMP. No significant cross-reactivity or interference between Human HAMP and analogues was observed.

Unopened test kits should be stored at 2 to 8 degree C upon receipt. Please refer to pdf manual for further storage instructions.

Samples: Serum, plasma, tissue homogenates and Cell lysates. Assay Type: Sandwich. Detection Range: 12.5 ng/ml-400 ng/ml. Sensitivity: 6.25 ng/ml

Intra-assay Precision: Intra-assay Precision (Precision within an assay): CV% is less than 8%. Three samples of known concentration were tested twenty times on one plate to assess. Inter-assay Precision (Precision between assays): CV% is less than 10%. Three samples of known concentration were tested in twenty assays to assess. Detection Wavelength: 450 nm. Sample Volume: 50-100ul

Principle of the Assay: This assay employs the quantitative sandwich enzyme immunoassay technique. Antibody specific for Hepc has been pre-coated onto a microplate. Standards and samples are pipetted into the wells with a Horseradish Peroxidase (HRP) conjugated antibody specific for Hepc. Following a wash to remove any unbound reagent, a substrate solution is added to the wells and color develops in proportion to the amount of Hepc bound in the initial step. The color development is stopped and the intensity of the color is measured.

10863973

NP_066998.1

NM_021175.2

P81172

9,408 Da

Iron Metabolism In Placenta Pathway (672461)

The product encoded by this gene is involved in the maintenance of iron homeostasis, and it is necessary for the regulation of iron storage in macrophages, and for intestinal iron absorption. The preproprotein is post-translationally cleaved into mature peptides of 20, 22 and 25 amino acids, and these active peptides are rich in cysteines, which form intramolecular bonds that stabilize their beta-sheet structures. These peptides exhibit antimicrobial activity against bacteria and fungi. Mutations in this gene cause hemochromatosis type 2B, also known as juvenile hemochromatosis, a disease caused by severe iron overload that results in cardiomyopathy, cirrhosis, and endocrine failure. [provided by RefSeq, Oct 2014]

Function: Liver-produced hormone that constitutes the main circulating regulator of iron absorption and distribution across tissues. Acts by promoting endocytosis and degradation of ferroportin, leading to the retention of iron in iron-exporting cells and decreased flow of iron into plasma. Controls the major flows of iron into plasma: absorption of dietary iron in the intestine, recycling of iron by macrophages, which phagocytose old erythrocytes and other cells, and mobilization of stored iron from hepatocytes (1 PublicationRef.9

48-Strip-Wells

565 USD

96-Strip-Wells

810

5x96-Strip-Wells

2750

10x96-Strip-Wells

5150