ELISA/assay

Human Immunoglobulin G4 (IgG4) ELISA Kit

MBS703648

48-Strip-Wells

450 USD

ELISA Kit

Human Immunoglobulin G4 (IgG4) ELISA Kit

Immunoglobulin G4 (IgG4)

Immunoglobulin G4 (IgG4)

inducible T-cell costimulator; Inducible T-cell co-stimulator; inducible T-cell costimulator; inducible costimulator; activation-inducible lymphocyte immunomediatory molecule; inducible T-cell co-stimulator

IgG4

ICOS; ICOS; AILIM; CD278; CVID1

Q53QY6_HUMAN

Human

Unopened test kits should be stored at 2 to 8 degree C upon receipt. Please refer to pdf manual for further storage instructions.

Samples: Serum, plasma

Principle of the Assay: The microtiter plate provided in this kit has been pre-coated with human IgG4. Standards or samples are then added to the appropriate microtiter plate wells with Horseradish Peroxidase (HRP) -conjugated antibody preparation specific for human IgG4, mix well and incubated. The more the amount of human IgG4 in samples, the less HRP-antibody bound by pre-coated human IgG4. Then a TMB (3,3',5,5' tetramethyl-benzidine) substrate solution is added to each well. And the color develops in opposite to the amount of human IgG4 in the sample. The color development is stopped and the intensity of the color is measured.

15029518

NP_036224.1

NM_012092.3

Q53QY6

22,625 Da

Adaptive Immune System Pathway (366160); Cell Adhesion Molecules (CAMs) Pathway (83069); Cell Adhesion Molecules (CAMs) Pathway (480); Costimulation By The CD28 Family Pathway (119552); Immune System Pathway (106386); Intestinal Immune Network For IgA Production Pathway (128760); Intestinal Immune Network For IgA Production Pathway (128670); Primary Immunodeficiency Pathway (83125); Primary Immunodeficiency Pathway (537); T Cell Receptor Signaling Pathway (83080)

The protein encoded by this gene belongs to the CD28 and CTLA-4 cell-surface receptor family. It forms homodimers and plays an important role in cell-cell signaling, immune responses, and regulation of cell proliferation. [provided by RefSeq, Jul 2008]

ICOS: Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up- regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up- regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre- activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes. Defects in ICOS are the cause of immunodeficiency common variable type 1 (CVID1). CVID1 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be lo. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral. Chromosomal Location of Human Ortholog: 2q33. Cellular Component: integral to plasma membrane; extracellular region; plasma membrane; external side of plasma membrane. Biological Process: cell-cell adhesion; T cell tolerance induction; T cell costimulation; immune response. Disease: Immunodeficiency, Common Variable, 2; Immunodeficiency, Common Variable, 1

48-Strip-Wells

450 USD

96-Strip-Wells

640

5x96-Strip-Wells

2435

10x96-Strip-Wells

4555