Rabbit lectin-like oxidized low density lipoprotein receptor 1, LOX1 ELISA Kit | MyBioSource MBS703594 product information

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Rabbit lectin-like oxidized low density lipoprotein receptor 1, LOX1 ELISA Kit

catalog :

MBS703594

quantity :

96 Strip Wells

price :

915 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS703594

products type :

ELISA Kit

products full name :

Rabbit lectin-like oxidized low density lipoprotein receptor 1, LOX1 ELISA Kit

products short name :

oxidized low density lipoprotein (lectin-like) receptor 1

products name syn :

Rabbit lectin-like oxidized low density lipoprotein receptor 1 (LOX1) ELISA kit; CLEC8A; LOX1; SCARE1; lectin-type oxidized LDL receptor 1; oxidised low density lipoprotein (lectin-like) receptor 1; scavenger receptor class E; member 1; oxidized low density lipoprotein (lectin-like) receptor 1

other names :

oxidized low-density lipoprotein receptor 1; Oxidized low-density lipoprotein receptor 1; oxidized low-density lipoprotein receptor 1; ox-LDL receptor 1; lectin-like oxLDL receptor 1; lectin-like oxidized LDL receptor 1; lectin-type oxidized LDL receptor 1; Lectin-like oxidized LDL receptor 1; LOX-1; Lectin-like oxLDL receptor 1; Lectin-type oxidized LDL receptor 1Cleaved into the following chain:Oxidized low-density lipoprotein receptor 1, soluble form

products gene name :

OLR1

other gene names :

OLR1; OLR1; LOX1; LOX-1; LOX1; Ox-LDL receptor 1; LOX-1; Lectin-like oxLDL receptor 1

uniprot entry name :

OLR1_RABIT

reactivity :

Rabbit

sequence length :

278

specificity :

This assay has high sensitivity and excellent specificity for detection of Rabbit OLR1. No significant cross-reactivity or interference between Rabbit OLR1 and analogues was observed.

storage stability :

Unopened test kits should be stored at 2 to 8 degree C upon receipt. Please refer to pdf manual for further storage instructions.

other info1 :

Intra-assay Precision: Intra-assay Precision (Precision within an assay): CV% is less than 8%. Three samples of known concentration were tested twenty times on one plate to assess. Inter-assay Precision (Precision between assays): CV% is less than 10%. Three samples of known concentration were tested in twenty assays to assess. Sample Type: serum, plasma, tissue homogenates. Detection Range: 0.312 ng/ml-20 ng/ml. Detection Wavelength: 450 nm. Sensitivity: 0.078 ng/ml

other info2 :

Sample Volume: 50-100ul. Protein Biological Process 1: Cell Adhesion. Protein Biological Process 3: Cell adhesion

products description :

Introduction: Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is one of the scavenger receptors that recognizes oxidized low-density lipoprotein as a major ligand. The placenta is a major source of prooxidant during pregnancy, and the level of placental oxidative stress increases rapidly at the end of the first trimester and tapers off later in gestation. Principle of the Assay: The microtiter plate provided in this kit has been pre-coated with an antibody specific to LOX1. Standards or samples are then added to the appropriate microtiter plate wells with a biotin-conjugated antibody preparation specific for LOX1 and Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. Then a TMB (3,3',5,5' tetramethyl-benzidine) substrate solution is added to each well. Only those wells that contain LOX1, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of a sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450 nm +/- 2 nm. The concentration of LOX1 in the samples is then determined by comparing the O.D. of the samples to the standard curve.

ncbi gi num :

130493907

ncbi acc num :

NP_001076102.1

ncbi gb acc num :

NM_001082633.1

uniprot acc num :

Q9XTA8

ncbi mol weight :

31,159 Da

ncbi pathways :

Cell Surface Interactions At The Vascular Wall Pathway 106062!!Hemostasis Pathway 106028!!PPAR Signaling Pathway 83042!!PPAR Signaling Pathway 450!!Phagosome Pathway 153910!!Phagosome Pathway 153859

uniprot summary :

Function: Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria

size :

96 Strip Wells

price :

915 USD

more info or order :

MyBioSource product webpage