Human Haptoglobin, Hpt/HP ELISA Kit | MyBioSource MBS702695 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Human Haptoglobin, Hpt/HP ELISA Kit

catalog :

MBS702695

quantity :

24-Strip-Wells (LIMIT 1)

price :

240 USD

product information

catalog number :

MBS702695

products type :

ELISA Kit

products full name :

Human Haptoglobin, Hpt/HP ELISA Kit

products short name :

[haptoglobin]

products name syn :

[Human Haptoglobin; Hpt/HP ELISA KIT; BP; HP2-ALPHA-2; HPA1S; MGC111141; binding peptide; haptoglobin alpha (1S) -beta; haptoglobin alpha (2FS) -beta; haptoglobin; alpha polypeptide; haptoglobin; beta polypeptide; Human Haptoglobin; Hpt/HP]

other names :

[haptoglobin isoform 2 preproprotein; Haptoglobin; haptoglobin; zonulin; binding peptide; haptoglobin alpha(1S)-beta; haptoglobin alpha(2FS)-beta; haptoglobin, beta polypeptide; haptoglobin, alpha polypeptide; haptoglobin; ZonulinCleaved into the following 2 chains:Haptoglobin alpha chain; Haptoglobin beta chain]

products gene name :

[HP]

other gene names :

[HP; HP; BP; HPA1S; HP2ALPHA2]

uniprot entry name :

HPT_HUMAN

reactivity :

Human

sequence length :

347

specificity :

This assay has high sensitivity and excellent specificity for detection of human hOGG1. No significant cross-reactivity or interference between human hOGG1 and analogues was observed.

storage stability :

Unopened test kits should be stored at 2 to 8 degree C upon receipt. Please refer to pdf manual for further storage instructions.

other info1 :

Samples: Serum, Tissue Homogenates, Cell Lysates. Assay Type: Quantitative Sandwich. Detection Range: 0.312 ng/ml-20 ng/ml. Sensitivity: 0.078 ng/ml.

other info2 :

Intra-assay Precision: Intra-assay Precision (Precision within an assay): CV%<8%. Three samples of known concentration were tested twenty times on one plate to assess. Inter-assay Precision: Inter-assay Precision (Precision between assays): CV%<10%. Three samples of known concentration were tested in twenty assays to assess.

products description :

Principle of the Assay: This assay employs the quantitative sandwich enzyme immunoassay technique. Antibody specific for hOGG1 has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and any hOGG1 present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for hOGG1 is added to the wells. After washing, avidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of hOGG1 bound in the initial step. The color development is stopped and the intensity of the color is measured.

ncbi gi num :

186910296

ncbi acc num :

NP_001119574.1

ncbi gb acc num :

NM_001126102.1

uniprot acc num :

P00738

ncbi mol weight :

45,205 Da

ncbi pathways :

Binding And Uptake Of Ligands By Scavenger Receptors Pathway (771599); Scavenging Of Heme From Plasma Pathway (771600); Amb2 Integrin Signaling Pathway (137945)

ncbi summary :

This gene encodes a preproprotein, which is processed to yield both alpha and beta chains, which subsequently combine as a tetramer to produce haptoglobin. Haptoglobin functions to bind free plasma hemoglobin, which allows degradative enzymes to gain access to the hemoglobin, while at the same time preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin. Mutations in this gene and/or its regulatory regions cause ahaptoglobinemia or hypohaptoglobinemia. This gene has also been linked to diabetic nephropathy, the incidence of coronary artery disease in type 1 diabetes, Crohn's disease, inflammatory disease behavior, primary sclerosing cholangitis, susceptibility to idiopathic Parkinson's disease, and a reduced incidence of Plasmodium falciparum malaria. A similar duplicated gene is located next to this gene on chromosome 16. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

uniprot summary :

Function: As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an Antimicrobial; Antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidely cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway.1 PublicationManual assertion based on experiment in:Ref.29

size1 :

24-Strip-Wells (LIMIT 1)

price1 :

240 USD

size2 :

48-Strip-Wells

price2 :

320

size3 :

96-Strip-Wells

price3 :

445

size4 :

5x96-Strip-Wells

price4 :

1880

size5 :

10x96-Strip-Wells

price5 :

3540