ELISA/assay

Human voltage-gated potassium channel antibody, VGKC-ab ELISA Kit

MBS702366

96 Strip Wells

915 USD

ELISA Kit

Human voltage-gated potassium channel antibody, VGKC-ab ELISA Kit

voltage-gated potassium channel antibody (VGKC-ab)

Human voltage-gated potassium channel antibody (VGKC-ab) ELISA Kit; voltage-gated potassium channel antibody (VGKC-ab)

voltage gated potassium channel; Potassium voltage-gated channel subfamily KQT member 1; potassium voltage-gated channel subfamily KQT member 1; slow delayed rectifier channel subunit; voltage-gated potassium channel subunit Kv7.1; kidney and cardiac voltage dependend K+ channel; IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1; potassium voltage-gated channel, KQT-like subfamily, member 1; IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1; KQT-like 1; Voltage-gated potassium channel subunit Kv7.1

KCNQ1; KCNQ1; LQT; RWS; WRS; LQT1; SQT2; ATFB1; ATFB3; JLNS1; KCNA8; KCNA9; Kv1.9; Kv7.1; KVLQT1; KCNA8; KCNA9; KVLQT1

KCNQ1_HUMAN

Human

581

Unopened test kits should be stored at 2 to 8 degree C upon receipt. Please refer to pdf manual for further storage instructions.

Sample Type: serum. Detection Wavelength: 450 nm

Sample Volume: 50-100ul

Principle of the Assay: The microtiter plate provided in this kit has been pre-coated with specificity antigen . Samples are then added to the appropriate microtiter plate wells and incubated. Then add Horseradish Peroxidase (HRP)-conjugated -anti-human immunoglobin to each well and incubate. Finally, substrate solutions are added to each well. The enzyme-substrate reaction is terminated by the addition of a sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450 nm +/- 2 nm. Calculate the valence of human anti-VGKC antibody in the samples.

2465515

AAC51781.1

P51787

61,474 Da

Adrenergic Signaling In Cardiomyocytes Pathway 908257!!Adrenergic Signaling In Cardiomyocytes Pathway 909696!!Cholinergic Synapse Pathway 217716!!Gastric Acid Secretion Pathway 154409!!Gastric Acid Secretion Pathway 154383!!Neuronal System Pathway 106513!!Pancreatic Secretion Pathway 169306!!Pancreatic Secretion Pathway 169295!!Potassium Channels Pathway 366221!!Protein Digestion And Absorption Pathway 172847

This gene encodes a voltage-gated potassium channel required for repolarization phase of the cardiac action potential. This protein can form heteromultimers with two other potassium channel proteins, KCNE1 and KCNE3. Mutations in this gene are associated with hereditary long QT syndrome 1 (also known as Romano-Ward syndrome), Jervell and Lange-Nielsen syndrome, and familial atrial fibrillation. This gene exhibits tissue-specific imprinting, with preferential expression from the maternal allele in some tissues, and biallelic expression in others. This gene is located in a region of chromosome 11 amongst other imprinted genes that are associated with Beckwith-Wiedemann syndrome (BWS), and itself has been shown to be disrupted by chromosomal rearrangements in patients with BWS. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2011]

Function: Probably important in cardiac repolarization. Associates with KCNE1 (MinK) to form the I(Ks) cardiac potassium current. Elicits a rapidly activating, potassium-selective outward current. Muscarinic agonist oxotremorine-M strongly suppresses KCNQ1/KCNE1 current in CHO cells in which cloned KCNQ1/KCNE1 channels were coexpressed with M1 muscarinic receptors. May associate also with KCNE3 (MiRP2) to form the potassium channel that is important for cyclic AMP-stimulated intestinal secretion of chloride ions, which is reduced in cystic fibrosis and pathologically stimulated in cholera and other forms of secretory diarrhea.

96 Strip Wells

915 USD