Human Complement fragment 3b recptor, C3bR ELISA Kit | MyBioSource MBS701777 product information

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Human Complement fragment 3b recptor, C3bR ELISA Kit

catalog :

MBS701777

quantity :

48-Strip-Wells

price :

510 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS701777

products type :

ELISA Kit

products full name :

Human Complement fragment 3b recptor, C3bR ELISA Kit

products short name :

Complement fragment 3b recptor, C3bR

products name syn :

Human Complement fragment 3b recptor; C3bR ELISA Kit; C3BR; C4BR; CD35; KN; C3-binding protein; C3b/C4b receptor; CD35 antigen; Knops blood group antigen; complement component receptor 1; complement receptor 1; Complement fragment 3b recptor; C3bR

other names :

complement receptor type 1 isoform F; Complement receptor type 1; complement receptor type 1; CD35 antigen; C3b/C4b receptor; C3-binding protein; Knops blood group antigen; complement component (3b/4b) receptor 1 (Knops blood group); C3b/C4b receptor; CD_antigen: CD35

products gene name :

C3bR

other gene names :

CR1; CR1; KN; C3BR; C4BR; CD35; C3BR

uniprot entry name :

CR1_HUMAN

reactivity :

Human

sequence length :

2039

specificity :

This assay has high sensitivity and excellent specificity for detection of Human C3bR. No significant cross-reactivity or interference between Human C3bR and analogues was observed.

storage stability :

Unopened test kits should be stored at 2 to 8 degree C upon receipt. Please refer to pdf manual for further storage instructions.

other info1 :

Samples: Serum, plasma, cerebrospinal fluid (CSF), cell culture supernates. Assay Type: Sandwich. Detection Range: 1.56 ng/ml-100 ng/ml. Sensitivity: 0.39 ng/ml

other info2 :

Intra-assay Precision: Intra-assay Precision (Precision within an assay): CV% is less than 8%. Three samples of known concentration were tested twenty times on one plate to assess. Inter-assay Precision (Precision between assays): CV% is less than 10%. Three samples of known concentration were tested in twenty assays to assess. Detection Wavelength: 450 nm. Sample Volume: 50-100ul. Protein Biological Process 1: Complement. Protein Biological Process 3: Complement pathway

products description :

Principle of the Assay: This assay employs the quantitative sandwich enzyme immunoassay technique. Antibody specific for C3bR has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and any C3bR present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for C3bR is added to the wells. After washing, avidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of C3bR bound in the initial step. The color development is stopped and the intensity of the color is measured.

ncbi gi num :

86793036

ncbi acc num :

NP_000564.2

ncbi gb acc num :

NM_000573.3

uniprot acc num :

P17927

ncbi mol weight :

223,663 Da

ncbi pathways :

Complement And Coagulation Cascades Pathway (198880); Complement And Coagulation Cascades Pathway (83073); Complement And Coagulation Cascades Pathway (484); Complement Cascade Pathway (106405); Hematopoietic Cell Lineage Pathway (83078); Hematopoietic Cell Lineage Pathway (489); Immune System Pathway (106386); Innate Immune System Pathway (106387); Legionellosis Pathway (469200); Legionellosis Pathway (469186)

ncbi summary :

This gene is a member of the receptors of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression of this protein and/or mutations in its gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus and sarcoidosis. Mutations in this gene have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria. Alternate allele-specific splice variants, encoding different isoforms, have been characterized. Additional allele specific isoforms, including a secreted form, have been described but have not been fully characterized. [provided by RefSeq, Jul 2008]

uniprot summary :

Function: Mediates cellular binding of particles and immune complexes that have activated complement.

size1 :

48-Strip-Wells

price1 :

510 USD

size2 :

96-Strip-Wells

price2 :

725

size3 :

5x96-Strip-Wells

price3 :

2565

size4 :

10x96-Strip-Wells

price4 :

4800

more info or order :

MyBioSource product webpage