catalog number :
MBS7017724
products type :
Recombinant Protein
products full name :
Recombinant Human Potassium channel subfamily K member 1 (KCNK1)
products short name :
[Potassium channel subfamily K member 1 (KCNK1)]
other names :
[potassium channel subfamily K member 1; Potassium channel subfamily K member 1; potassium channel subfamily K member 1; potassium two pore domain channel subfamily K member 1; Inward rectifying potassium channel protein TWIK-1]
products gene name :
[KCNK1]
products gene name syn :
[HOHO1; KCNO1; TWIK1]
other gene names :
[KCNK1; KCNK1; DPK; HOHO; K2P1; KCNO1; TWIK1; K2p1.1; TWIK-1; ]
uniprot entry name :
KCNK1_HUMAN
host :
Cell Free Expression
sequence positions :
[1-336aa; Full length protein]
sequence :
RRFLEEHECLSEQQLEQFLGRVLEASNYGVSVLSNASGNWNWDFTSALFFASTVLSTTGY GHTVPLSDGGKAFCIIYSVIGIPFTLLFLTAVVQRITVHVTRRPVLYFHIRWGFSKQVVA IVHAVLLGFVTVSCFFFIPAAVFSVLEDDWNFLESFYFCFISLSTIGLGDYVPGEGYNQK FRELYKIGITCYLLLGLIAMLVVLETFCELHELKKFRKMFYVKKDKDEDQVHIIEHDQLS FSSITDQAAGMKEDQKQNEPFVATQSSACVDGPANH
MLQSLAGSSCVRLVERHRSAWCFGFLVLGYLLYLVFGAV
VFSSVELPYEDLLRQELRKLK
form :
Liquid containing glycerol
storage stability :
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C. Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
app notes :
This is a recombinant transmembrane protein expressed in a cell-free expression system.
other info1 :
Species: Human. Storage Buffer: Tris-based buffer, 50% glycerol.
products categories :
Transmembrane Protein
ncbi acc num :
NP_002236.1
ncbi gb acc num :
NM_002245.3
ncbi mol weight :
38,143 Da
ncbi pathways :
Cardiac Conduction Pathway (1339115); Muscle Contraction Pathway (1269868); Neuronal System Pathway (1268763); Phase 4 - Resting Membrane Potential Pathway (1339116); Potassium Channels Pathway (1268821); Tandem Of Pore Domain In A Weak Inwardly Rectifying K+ Channels (TWIK) Pathway (1268832); Tandem Pore Domain Potassium Channels Pathway (1268831)
ncbi summary :
This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The product of this gene has not been shown to be a functional channel, however, it may require other non-pore-forming proteins for activity. [provided by RefSeq, Jul 2008]
uniprot summary :
KCNK1: Weakly inward rectifying potassium channel. Homodimer (Potential). Widely expressed with high levels in heart and brain and lower levels in placenta, lung, liver and kidney. Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. Protein type: Membrane protein, multi-pass; Membrane protein, integral. Chromosomal Location of Human Ortholog: 1q42-q43. Cellular Component: apical plasma membrane; brush border membrane; cell junction; cytoplasmic membrane-bound vesicle; dendrite; integral to membrane; integral to plasma membrane; perikaryon; plasma membrane; recycling endosome; synapse; voltage-gated potassium channel complex. Molecular Function: inward rectifier potassium channel activity; potassium channel activity; potassium ion leak channel activity; sodium channel activity; voltage-gated potassium channel activity. Biological Process: potassium ion transport; regulation of resting membrane potential; response to nicotine; stabilization of membrane potential