ELISA/assay

Human low-density lipoprotein-receptor-related protein, LRP-6 ELISA Kit

MBS701523

24-Strip-Wells (LIMIT 1)

240 USD

ELISA Kit

Human low-density lipoprotein-receptor-related protein, LRP-6 ELISA Kit

[low density lipoprotein receptor-related protein 6]

[Human low-density lipoprotein-receptor-related protein; LRP-6 ELISA Kit; ADCAD2; FLJ90062; FLJ90421; ; low density lipoprotein receptor-related protein 6]

[low-density lipoprotein receptor-related protein 6; Low-density lipoprotein receptor-related protein 6; low-density lipoprotein receptor-related protein 6; LRP-6; low density lipoprotein receptor-related protein 6]

[LRP6]

[LRP6; LRP6; ADCAD2; LRP-6]

LRP6_HUMAN

Human

1613

This assay has high sensitivity and excellent specificity for detection of human LRP-6. No significant cross-reactivity or interference between human LRP-6 and analogues was observed.

Unopened test kits should be stored at 2 to 8 degree C upon receipt. Please refer to pdf manual for further storage instructions.

Typical Testing Data/Standard Curve (for reference only)

Samples: serum, tissue homogenates, cell lysates. Assay Type: Sandwich (Quantitative). Detection Range: 0.312 ng/ml-20 ng/ml. Sensitivity: Typically less than 0.078 ng/ml

Intra-assay Precision: Intra-assay Precision (Precision within an assay): CV%<8%. Three samples of known concentration were tested twenty times on one plate to assess. Inter-assay Precision: Inter-assay Precision (Precision between assays): CV%<10%. Three samples of known concentration were tested in twenty assays to assess.

148727288

NP_002327.2

NM_002336.2

O75581

180,429 Da

Canonical Wnt Signaling Pathway (138032); Disease Pathway (530764); MicroRNAs In Cardiomyocyte Hypertrophy Pathway (198784); Presenilin Action In Notch And Wnt Signaling Pathway (137914); RNF Mutants Show Enhanced WNT Signaling And Proliferation Pathway (1016209); Signal Transduction Pathway (477114); Signaling By WNT In Cancer Pathway (1016191); Signaling By Wnt Pathway (106510); TCF Dependent Signaling In Response To WNT Pathway (980475); Wnt Signaling Pathway NetPath (198799)

This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined.[provided by RefSeq, Dec 2009]

Function: Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Required for posterior patterning of the epiblast during gastrulation 10 PublicationsManual assertion based on experiment in:Ref.4

24-Strip-Wells (LIMIT 1)

240 USD

48-Strip-Wells

550

96-Strip-Wells

795

5x96-Strip-Wells

2890

10x96-Strip-Wells

5465