PDE6D Antibody | MyBioSource MBS7005086 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

PDE6D Antibody

catalog :

MBS7005086

quantity :

0.05 mg

price :

160 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, ELISA, immunohistochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

image

image 1 :

Western blot. All lanes: PDE6D antibody at 1.5ug/ml. Lane 1: A549 whole cell lysate. Lane 2: MCF-7 whole cell lysate. Secondary. Goat polyclonal to Rabbit IgG at 1/10000 dilution. Predicted band size: 18 kDa. Observed band size: 18 kDa.

image 2 :

Immunohistochemistry of paraffin-embedded human breast cancer using MBS7005086 at dilution of 1:100

image 3 :

Immunohistochemistry of paraffin-embedded human small intestine tissue using MBS7005086 at dilution of 1:100

product information

catalog number :

MBS7005086

products type :

Antibody

products full name :

PDE6D Antibody

products short name :

[PDE6D]

products name syn :

[Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (GMP-PDEdelta) (Proteinp17), PDE6D, PDED]

other names :

[retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta isoform 2; Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta; phosphodiesterase 6D; Protein p17]

products gene name :

[PDE6D]

other gene names :

[PDE6D; PDE6D; PDED; JBTS22; PDED; GMP-PDE delta]

uniprot entry name :

PDE6D_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human

purity :

Antigen Affinity Purified

form :

Liquid

storage stability :

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

tested application :

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

app notes :

Recommended dilution: WB:1:500-1:2000, IHC:1:20-1:200

image1 heading :

Western Blot (WB)

image2 heading :

Immunohistochemistry (IHC)

image3 heading :

Immunohistochemistry (IHC)

other info1 :

Immunogen: Recombinant Human Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta protein (1-150AA). Conjugate: Non-conjugated. Storage Buffer: Preservative:0.03% Proclin 300. Constituents: 50% Glycerol, 0.01M PBS, PH 7.4. Species: Human. Research Area: Signal Transduction

products description :

Promotes the release of prenylated target proteins from cellular membranes (PubMed:9712853). Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location (PubMed:22002721, PubMed:23698361). Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E (PubMed:24166846). Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI) (By similarity). Increases the affinity of ARL3 for GTP by several orders of magnitude. Stabilizes ARL3-GTP by decreasing the nucleotide dissociation rate (By similarity).

ncbi gi num :

597518021

ncbi acc num :

NP_001277947.1

ncbi gb acc num :

NM_001291018.1

uniprot acc num :

O43924

ncbi pathways :

ARL13B-mediated Ciliary Trafficking Of INPP5E Pathway (1268852); Assembly Of The Primary Cilium Pathway (1268846); Cargo Trafficking To The Periciliary Membrane Pathway (1268848); Organelle Biogenesis And Maintenance Pathway (1268838); Purine Metabolism Pathway (82944); Purine Metabolism Pathway (307)

ncbi summary :

This gene encodes the delta subunit of rod-specific photoreceptor phosphodiesterase (PDE), a key enzyme in the phototransduction cascade. A similar protein in cow functions in solubilizing membrane-bound PDE. In addition to its role in the PDE complex, the encoded protein is thought to bind to prenyl groups of proteins to target them to subcellular organelles called cilia. Mutations in this gene are associated with Joubert syndrome-22. Alternative splicing results in multiple splice variants. [provided by RefSeq, Mar 2014]

uniprot summary :

PDE6D: Acts as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude and does so by decreasing the nucleotide dissociation rate. Stabilizes Arl3-GTP by decreasing the nucleotide dissociation. Belongs to the PDE6D/unc-119 family. Chromosomal Location of Human Ortholog: 2q35-q36. Cellular Component: cytoplasmic vesicle; cytoplasmic vesicle membrane; cytoskeleton; cytosol. Molecular Function: 3',5'-cyclic-nucleotide phosphodiesterase activity; GTPase inhibitor activity; protein binding; Rab GTPase binding. Biological Process: metabolic process; organelle organization and biogenesis; response to stimulus; visual perception. Disease: Joubert Syndrome 22

size1 :

0.05 mg

price1 :

160 USD

size2 :

0.1 mg

price2 :

235

more info or order :

MyBioSource product webpage