Human Bone morphogenetic protein receptor 1A, BMPR-1A ELISA Kit | MyBioSource MBS700462 product information

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Human Bone morphogenetic protein receptor 1A, BMPR-1A ELISA Kit

catalog :

MBS700462

quantity :

48-Strip-Wells

price :

510 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS700462

products type :

ELISA Kit

products full name :

Human Bone morphogenetic protein receptor 1A, BMPR-1A ELISA Kit

products short name :

bone morphogenetic protein receptor, type IA

products name syn :

Human Bone morphogenetic protein receptor 1A; BMPR-1A ELISA Kit; 10q23del; ACVRLK3; ALK3; CD292; SKR5; OTTHUMP00000020014; activin A receptor; type II-like kinase 3; serine/threonine-protein kinase receptor R5; bone morphogenetic protein receptor; type IA

other names :

bone morphogenetic protein receptor type-1A; Bone morphogenetic protein receptor type-1A; bone morphogenetic protein receptor type-1A; ALK-3; BMPR-1A; BMP type-1A receptor; activin receptor-like kinase 3; activin A receptor, type II-like kinase 3; serine/threonine-protein kinase receptor R5; bone morphogenetic protein receptor, type IA; Activin receptor-like kinase 3; ALK-3; Serine/threonine-protein kinase receptor R5; SKR5; CD_antigen: CD292

products gene name :

BMPR1A

other gene names :

BMPR1A; BMPR1A; ALK3; SKR5; CD292; ACVRLK3; 10q23del; ACVRLK3; ALK3; BMP type-1A receptor; BMPR-1A; ALK-3; SKR5

uniprot entry name :

BMR1A_HUMAN

reactivity :

Human

sequence length :

532

specificity :

This assay has high sensitivity and excellent specificity for detection of Human BMPR1A. No significant cross-reactivity or interference between Human BMPR1A and analogues was observed.

storage stability :

Unopened test kits should be stored at 2 to 8 degree C upon receipt. Please refer to pdf manual for further storage instructions.

other info1 :

Samples: Serum, plasma, tissue homogenates, Cell lysates. Assay Type: Sandwich. Detection Range: 0.312 ng/ml-20 ng/ml. Sensitivity: 0.078 ng/ml

other info2 :

Intra-assay Precision: Intra-assay Precision (Precision within an assay): CV% is less than 8%. Three samples of known concentration were tested twenty times on one plate to assess. Inter-assay Precision (Precision between assays): CV% is less than 10%. Three samples of known concentration were tested in twenty assays to assess. Detection Wavelength: 450 nm. Sample Volume: 50-100ul

products description :

For samples: For the quantitative determination of human bone morphogenetic protein receptor 1A (BMPR-1A) concentrations in serum, plasma, tissue homogenates. PRINCIPLE OF THE ASSAY This assay employs the quantitative sandwich enzyme immunoassay technique. Antibody specific for BMPR-1A has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and any BMPR-1A present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for BMPR-1A is added to the wells. After washing, avidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of BMPR-1A bound in the initial step. The color development is stopped and the intensity of the color is measured.

ncbi gi num :

41349437

ncbi acc num :

NP_004320.2

ncbi gb acc num :

NM_004329.2

uniprot acc num :

P36894

ncbi mol weight :

60,198 Da

ncbi pathways :

BMP Signalling And Regulation Pathway (198910); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); Endochondral Ossification Pathway (198812); Heart Development Pathway (198802); Hippo Signaling Pathway (749777); Hippo Signaling Pathway (750388); Integrated Breast Cancer Pathway (219801); Signal Transduction Pathway (477114); Signaling By BMP Pathway (106336)

ncbi summary :

The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. [provided by RefSeq, Jul 2008]

uniprot summary :

Function: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP-2 and BMP-4. Catalytic activity: ATP + [receptor-protein] = ADP + [receptor-protein] phosphate. Cofactor: Magnesium or manganese

size1 :

48-Strip-Wells

price1 :

510 USD

size2 :

96-Strip-Wells

price2 :

725

size3 :

5x96-Strip-Wells

price3 :

2565

size4 :

10x96-Strip-Wells

price4 :

4800

more info or order :

MyBioSource product webpage