Rabbit anti-human Vasopressin-neurophysin 2-copeptin polyclonal Antibody | MyBioSource MBS7003343 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Rabbit anti-human Vasopressin-neurophysin 2-copeptin polyclonal Antibody

catalog :

MBS7003343

quantity :

0.05 mg

price :

160 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, rat

application :

western blot, ELISA, immunohistochemistry

more info or order :

MyBioSource product webpage

image

image 1 :

All lanes: Vasopressin-neurophysin 2-copeptin antibody at 2ug/ml+rat gonad tissue. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 18kDa. Observed band size: 18kDa

image 2 :

Immunohistochemistry of paraffin-embedded human breast cancer using MBS7003343 at dilution 1:100

product information

catalog number :

MBS7003343

products type :

Antibody

products full name :

Rabbit anti-human Vasopressin-neurophysin 2-copeptin polyclonal Antibody

products short name :

[Vasopressin-neurophysin 2-copeptin]

products name syn :

[Vasopressin-neurophysin 2-copeptin (AVP-NPII) [Cleaved into: Arg-vasopressin (Arginine-vasopressin); Neurophysin 2 (Neurophysin-II); Copeptin], AVP, ARVP VP]

other names :

[vasopressin-neurophysin 2-copeptin preproprotein; Vasopressin-neurophysin 2-copeptin; vasopressin-neurophysin 2-copeptin; arginine vasopressin; AVP-NPII]

products gene name syn :

[AVP]

other gene names :

[AVP; AVP; VP; ADH; ARVP; AVRP; AVP-NPII; ARVP; VP]

uniprot entry name :

NEU2_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human, Rat

purity :

>95%, Protein G purified

form :

Liquid

storage stability :

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

tested application :

ELISA, Western Blot (WB), Immunohistochemistry (IHC)

app notes :

Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200

image1 heading :

Western Blot (WB)

image2 heading :

Immunohistochemistry (IHC)

other info1 :

Immunogen: Recombinant Human Vasopressin-neurophysin 2-copeptin protein (126-164AA). Conjugate: Non-conjugated. Storage Buffer: Preservative: 0.03% Proclin 300. Constituents: 50% Glycerol, 0.01M PBS, PH 7.4. Species: Human. Research Area: Neuroscience

other info2 :

Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-27094 / sc-7811

products description :

Neurophysin 2 specifically binds vasopressin. Vasopressin has a direct antidiuretic action on the kidney, it also causes vasoconstriction of the peripheral vessels. This gene encodes a precursor protein consisting of arginine vasopressin and two associated proteins, neurophysin II and a glycopeptide, copeptin. Arginine vasopressin is a posterior pituitary hormone which is synthesized in the supraoptic nucleus and paraventricular nucleus of the hypothalamus. Along with its carrier protein, neurophysin II, it is packaged into neurosecretory vesicles and transported axonally to the nerve endings in the neurohypophysis where it is either stored or secreted into the bloodstream. The precursor is thought to be activated while it is being transported along the axon to the posterior pituitary. Arginine vasopressin acts as a growth factor by enhancing pH regulation through acid-base transport systems. It has a direct antidiuretic action on the kidney, and also causes vasoconstriction of the peripheral vessels. This hormone can contract smooth muscle during parturition and lactation. It is also involved in cognition, tolerance, adaptation and complex sexual and maternal behaviour, as well as in the regulation of water excretion and cardiovascular functions. Mutations in this gene cause autosomal dominant neurohypophyseal diabetes insipidus (ADNDI).

ncbi gi num :

13259533

ncbi acc num :

NP_000481.2

ncbi gb acc num :

NM_000490.4

uniprot acc num :

P01185

ncbi pathways :

Aquaporin-mediated Transport Pathway (1269944); BMAL1:CLOCK,NPAS2 Activates Circadian Gene Expression Pathway (1269872); Circadian Clock Pathway (1269871); Class A/1 (Rhodopsin-like Receptors) Pathway (1269545); Defective AVP Causes Neurohypophyseal Diabetes Insipidus (NDI) Pathway (1309124); Disease Pathway (1268854); Disorders Of Transmembrane Transporters Pathway (1268932); G Alpha (q) Signalling Events Pathway (1269578); G Alpha (s) Signalling Events Pathway (1269575); GPCR Downstream Signaling Pathway (1269574)

ncbi summary :

This gene encodes a member of the vasopressin/oxytocin family and preproprotein that is proteolytically processed to generate multiple protein products. These products include the neuropeptide hormone arginine vasopressin, and two other peptides, neurophysin 2 and copeptin. Arginine vasopressin is a posterior pituitary hormone that is synthesized in the supraoptic nucleus and paraventricular nucleus of the hypothalamus. Along with its carrier protein, neurophysin 2, it is packaged into neurosecretory vesicles and transported axonally to the nerve endings in the neurohypophysis where it is either stored or secreted into the bloodstream. The precursor is thought to be activated while it is being transported along the axon to the posterior pituitary. Arginine vasopressin acts as a growth factor by enhancing pH regulation through acid-base transport systems. It has a direct antidiuretic action on the kidney, and also causes vasoconstriction of the peripheral vessels. This hormone can contract smooth muscle during parturition and lactation. It is also involved in cognition, tolerance, adaptation and complex sexual and maternal behaviour, as well as in the regulation of water excretion and cardiovascular functions. Mutations in this gene cause autosomal dominant neurohypophyseal diabetes insipidus (ADNDI). This gene is present in a gene cluster with the related gene oxytocin on chromosome 20. [provided by RefSeq, Nov 2015]

uniprot summary :

AVP: Neurophysin 2 specifically binds vasopressin. Defects in AVP are the cause of diabetes insipidus, neurohypophyseal (NDI). A disease characterized by persistent thirst, polydipsia and polyuria. Affected individuals are apparently normal at birth, but characteristically develop symptoms of vasopression deficiency during childhood. Belongs to the vasopressin/oxytocin family. Protein type: Secreted, signal peptide; Hormone; Secreted. Chromosomal Location of Human Ortholog: 20p13. Cellular Component: cytosol; dendrite; extracellular region; extracellular space; secretory granule. Molecular Function: caspase inhibitor activity; neurohypophyseal hormone activity; neuropeptide hormone activity; protein kinase activity; receptor binding; signal transducer activity; V1A vasopressin receptor binding; V1B vasopressin receptor binding. Biological Process: cell-cell signaling; circadian rhythm; elevation of cytosolic calcium ion concentration; generation of precursor metabolites and energy; grooming behavior; hyperosmotic salinity response; locomotory behavior; maternal behavior; negative regulation of apoptosis; negative regulation of caspase activity; negative regulation of female receptivity; negative regulation of transmission of nerve impulse; penile erection; positive regulation of cAMP biosynthetic process; positive regulation of cell growth; positive regulation of cell proliferation; positive regulation of cellular pH reduction; positive regulation of glutamate secretion; positive regulation of peptidyl-serine phosphorylation; positive regulation of prostaglandin biosynthetic process; positive regulation of systemic arterial blood pressure; positive regulation of vasoconstriction; renal water homeostasis; response to ethanol; response to nicotine; response to testosterone stimulus; signal transduction; social behavior; sodium-independent organic anion transport; transmembrane transport; vasoconstriction; water transport. Disease: Diabetes Insipidus, Neurohypophyseal

size1 :

0.05 mg

price1 :

160 USD

size2 :

0.1 mg

price2 :

235

more info or order :

MyBioSource product webpage