Human CC-Chemokine Receptor 2, CCR2 ELISA Kit | MyBioSource MBS700302 product information

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Human CC-Chemokine Receptor 2, CCR2 ELISA Kit

catalog :

MBS700302

quantity :

48-Strip-Wells

price :

565 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS700302

products type :

ELISA Kit

products full name :

Human CC-Chemokine Receptor 2, CCR2 ELISA Kit

products short name :

chemokine (C-C motif) receptor 2

products name syn :

Human CC-Chemokine Receptor 2; CCR2 ELISA Kit; CC-CKR-2; CCR2A; CCR2B; CD192; CKR2; CKR2A; CKR2B; CMKBR2; MCP-1-R; MCP-1 receptor; chemokine (C-C) receptor 2; monocyte chemoattractant protein 1 receptor; monocyte chemotactic protein 1 receptor; chemokine (C-C motif) receptor 2

other names :

C-C chemokine receptor type 2 isoform A; C-C chemokine receptor type 2; C-C chemokine receptor type 2; MCP-1 receptor; monocyte chemotactic protein 1 receptor; monocyte chemoattractant protein 1 receptor; chemokine (C-C motif) receptor 2; Monocyte chemoattractant protein 1 receptor; MCP-1-R; CD_antigen: CD192

products gene name :

CCR2

other gene names :

CCR2; CCR2; CKR2; CCR-2; CCR2A; CCR2B; CD192; CKR2A; CKR2B; CMKBR2; MCP-1-R; CC-CKR-2; CMKBR2; C-C CKR-2; CC-CKR-2; CCR-2; CCR2; MCP-1-R

uniprot entry name :

CCR2_HUMAN

reactivity :

Human

sequence length :

374

specificity :

This assay has high sensitivity and excellent specificity for detection of human CCR2. No significant cross-reactivity or interference between human CCR2 and analogues was observed.

storage stability :

Unopened test kits should be stored at 2 to 8 degree C upon receipt. Please refer to pdf manual for further storage instructions.

other info1 :

Samples: Serum, plasma, tissue homogenates, cerebrospinal fluid (CSF). Assay Type: Sandwich. Detection Range: 23.44 pg/ml -1500 pg/ml. Sensitivity: The minimum detectable dose of human CCR2 is typically less than 5.86 pg/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations.

other info2 :

Intra-assay Precision: Intra-assay Precision (Precision within an assay): CV%<8%. Three samples of known concentration were tested twenty times on one plate to assess. Inter-assay Precision: Inter-assay Precision (Precision between assays): CV%<10%. Three samples of known concentration were tested in twenty assays to assess.

products description :

Principle of the assay: This assay employs the quantitative sandwich enzyme immunoassay technique. Antibody specific for CCR2 has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and any CCR2 present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for CCR2 is added to the wells. After washing, avidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of CCR2 bound in the initial step. The color development is stopped and the intensity of the color is measured.

ncbi gi num :

183979980

ncbi acc num :

NP_001116513.2

ncbi gb acc num :

NM_001123041.2

uniprot acc num :

P41597

ncbi mol weight :

41,915 Da

ncbi pathways :

Beta Defensins Pathway (530759); Chemokine Receptors Bind Chemokines Pathway (106359); Chemokine Signaling Pathway (99051); Chemokine Signaling Pathway (96864); Class A/1 (Rhodopsin-like Receptors) Pathway (106357); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); Defensins Pathway (530757); G Alpha (i) Signalling Events Pathway (119550); GPCR Downstream Signaling Pathway (119548)

ncbi summary :

This gene encodes two isoforms of a receptor for monocyte chemoattractant protein-1, a chemokine which specifically mediates monocyte chemotaxis. Monocyte chemoattractant protein-1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. The receptors encoded by this gene mediate agonist-dependent calcium mobilization and inhibition of adenylyl cyclase. This gene is located in the chemokine receptor gene cluster region. Two alternatively spliced transcript variants are expressed by the gene. [provided by RefSeq, Mar 2009]

uniprot summary :

Function: Receptor for the CCL2, CCL7 and CCL13 chemokines. Transduces a signal by increasing intracellular calcium ion levels. Alternative coreceptor with CD4 for HIV-1 infection.1 PublicationManual assertion based on experiment in:Ref.14

size1 :

48-Strip-Wells

price1 :

565 USD

size2 :

96-Strip-Wells

price2 :

810

size3 :

5x96-Strip-Wells

price3 :

2750

size4 :

10x96-Strip-Wells

price4 :

5150

more info or order :

MyBioSource product webpage