human leukocyte immunoglobulin-like receptor subfamily B member 4, LILRB4 ELISA Kit | MyBioSource MBS700296 product information

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

human leukocyte immunoglobulin-like receptor subfamily B member 4, LILRB4 ELISA Kit

catalog :

MBS700296

quantity :

48-Strip-Wells

price :

510 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS700296

products type :

ELISA Kit

products full name :

human leukocyte immunoglobulin-like receptor subfamily B member 4, LILRB4 ELISA Kit

products short name :

leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains) , member 4

products name syn :

human leukocyte immunoglobulin-like receptor subfamily B member 4; LILRB4 ELISA Kit; CD85K; HM18; ILT3; LILRB5; LIR-5; LIR5; OTTHUMP00000068605; immunoglobulin-like transcript 3; leukocyte immunoglobulin-like receptor 5; leukocyte immunoglobulin-like receptor subfamily B member 4 solub; leukocyte immunoglobulin-like receptor; subfamily B (with TM and ITIM domains); member 4

other names :

leukocyte immunoglobulin-like receptor subfamily B member 4 isoform 1; Leukocyte immunoglobulin-like receptor subfamily B member 4; leukocyte immunoglobulin-like receptor subfamily B member 4; immunoglobulin-like transcript 3; CD85 antigen-like family member K; monocyte inhibitory receptor HM18; leukocyte immunoglobulin-like receptor 5; leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4; CD85 antigen-like family member K; Immunoglobulin-like transcript 3; ILT-3; Leukocyte immunoglobulin-like receptor 5; LIR-5; Monocyte inhibitory receptor HM18; CD_antigen: CD85k

products gene name :

LILRB4

other gene names :

LILRB4; LILRB4; ILT3; LIR5; CD85K; ILT-3; LIR-5; ILT3; LIR5; ILT-3; LIR-5

uniprot entry name :

LIRB4_HUMAN

reactivity :

Human

sequence length :

448

specificity :

This assay has high sensitivity and excellent specificity for detection of human LILRB4. No significant cross-reactivity or interference between human LILRB4 and analogues was observed.

storage stability :

Unopened test kits should be stored at 2 to 8 degree C upon receipt. Please refer to pdf manual for further storage instructions.

other info1 :

Samples: Serum, plasma, cell culture supernates, cell lysates. Assay Type: Sandwich. Detection Range: 31.25 pg/ml-2000 pg/ml. Sensitivity: Typically less than 7.81 pg/ml

other info2 :

Intra-assay Precision: Intra-assay Precision (Precision within an assay): CV%<8%. Three samples of known concentration were tested twenty times on one plate to assess. Inter-assay Precision: Inter-assay Precision (Precision between assays): CV%<10%. Three samples of known concentration were tested in twenty assays to assess.

products description :

Principle of the Assay: This assay employs the quantitative sandwich enzyme immunoassay technique. Antibody specific for LILRB4 has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and any LILRB4 present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for LILRB4 is added to the wells. After washing, avidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of LILRB4 bound in the initial step. The color development is stopped and the intensity of the color is measured.

ncbi gi num :

618857484

ncbi acc num :

NP_001265355.2

ncbi gb acc num :

NM_001278426.3

uniprot acc num :

Q8NHJ6

ncbi mol weight :

49,356 Da

ncbi pathways :

Adaptive Immune System Pathway (366160); Immune System Pathway (106386); Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway (106413); Osteoclast Differentiation Pathway (193147); Osteoclast Differentiation Pathway (193096)

ncbi summary :

This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. The receptor can also function in antigen capture and presentation. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

uniprot summary :

Function: Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Involved in the down-regulation of the immune response and the development of tolerance, e.g. towards transplants. Interferes with TNFRSF5-signaling and NF-kappa-B up-regulation. Inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.2 PublicationsManual assertion based on experiment in:Ref.9

size1 :

48-Strip-Wells

price1 :

510 USD

size2 :

96-Strip-Wells

price2 :

725

size3 :

5x96-Strip-Wells

price3 :

2565

size4 :

10x96-Strip-Wells

price4 :

4800

more info or order :

MyBioSource product webpage