Rabbit anti-human Thyroid hormone receptor alpha polyclonal Antibody(THRA) | MyBioSource MBS7002939 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Rabbit anti-human Thyroid hormone receptor alpha polyclonal Antibody(THRA)

catalog :

MBS7002939

quantity :

0.05 mg

price :

160 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, ELISA, immunohistochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

image

image 1 :

Western blot. All lanes: Thyroid hormone receptor alpha polyclonal antibody at 2ug/ml. Lane 1:Jurkat whole cell lysate. Lane 2:A431 whole cell lysate. Secondary. Goat polyclonal to rabbit at 1/10000 dilution. Predicted band size: 55,47,51 kDa. Observed band size: 55 kDa.

image 2 :

Immunohistochemistry of paraffin-embedded human colon cancer using MBS7002939 at dilution 1:100

image 3 :

Immunohistochemistry of paraffin-embedded human breast cancer using MBS7002939 at dilution 1:100

product information

catalog number :

MBS7002939

products type :

Antibody

products full name :

Rabbit anti-human Thyroid hormone receptor alpha polyclonal Antibody(THRA)

products short name :

[Thyroid hormone receptor alpha]

products name syn :

[Thyroid hormone receptor alpha (Nuclear receptor subfamily 1 group A member 1) (V-erbA-related protein 7) (EAR-7) (c-erbA-1) (c-erbA-alpha), THRA, EAR7 ERBA1 NR1A1 THRA1 THRA2]

other names :

[thyroid hormone receptor alpha isoform 3; Thyroid hormone receptor alpha; thyroid hormone receptor alpha; thyroid hormone receptor, alpha; Nuclear receptor subfamily 1 group A member 1; V-erbA-related protein 7; EAR-7; c-erbA-1; c-erbA-alpha]

other gene names :

[THRA; THRA; AR7; EAR7; ERBA; CHNG6; ERBA1; NR1A1; THRA1; THRA2; ERB-T-1; c-ERBA-1; EAR7; ERBA1; NR1A1; THRA1; THRA2; EAR-7]

uniprot entry name :

THA_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human

sequence length :

451

purity :

>95%, Protein G purified

form :

Liquid

storage stability :

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

tested application :

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

app notes :

WB:1:1000-1:5000. IHC:1:20-1:200

image1 heading :

Western Blot (WB)

image2 heading :

Immunohistochemistry (IHC)

image3 heading :

Immunohistochemistry (IHC)

other info1 :

Immunogen: Recombinant Human Thyroid hormone receptor alpha protein (1-490AA). Research Area: Signal Transduction. Target Names: THRA

other info2 :

Conjugation: Non-conjugated. Buffer: Preservative: 0.03% Proclin 300. Constituents: 50% Glycerol, 0.01M PBS, PH 7.4. Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-10819 / sc-772

products description :

Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.

ncbi gi num :

300116307

ncbi acc num :

NP_001177847.1

ncbi gb acc num :

NM_001190918.1

uniprot acc num :

P10827

ncbi pathways :

Endochondral Ossification Pathway (198812); Gene Expression Pathway (1269649); Generic Transcription Pathway (1269650); Neuroactive Ligand-receptor Interaction Pathway (83053); Neuroactive Ligand-receptor Interaction Pathway (462); Nuclear Receptor Transcription Pathway (1269652); Nuclear Receptors Pathway (198848); Thyroid Hormone Signaling Pathway (946598)

ncbi summary :

The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

uniprot summary :

TR-alpha: nuclear hormone receptor and transcription factor. High affinity receptor for triiodothyronine. Interacts with SRC-3 and NCOA6 coactivators, leading to a strong increase of transcription of target genes. Four splice variant isoforms have been described. Protein type: Transcription factor; Nuclear receptor; DNA-binding. Chromosomal Location of Human Ortholog: 17q11.2. Cellular Component: cytosol; mitochondrion; nucleoplasm; nucleus. Molecular Function: chromatin DNA binding; protein binding; protein complex binding; protein domain specific binding; protein heterodimerization activity; protein homodimerization activity; RNA polymerase II transcription factor activity, enhancer binding; sequence-specific DNA binding; steroid hormone receptor activity; TATA-binding protein binding; thyroid hormone receptor activity; transcription factor activity; transcription factor binding; zinc ion binding. Biological Process: adrenal gland development; brain development; cartilage condensation; cytoplasmic sequestering of transcription factor; embryonic organ development; erythrocyte differentiation; female courtship behavior; gene expression; gut development; hormone-mediated signaling; intracellular receptor-mediated signaling pathway; kidney development; learning and/or memory; liver development; negative regulation of transcription factor activity; negative regulation of transcription, DNA-dependent; negative regulation of transcriptional preinitiation complex assembly; ossification; positive regulation of female receptivity; positive regulation of transcription from RNA polymerase II promoter; regulation of heart contraction; regulation of lipid catabolic process; regulation of myeloid cell apoptosis; regulation of transcription from RNA polymerase II promoter; response to cold; response to drug; response to nutrient levels; steroid hormone mediated signaling; thyroid gland development; transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter. Disease: Hypothyroidism, Congenital, Nongoitrous, 6

size1 :

0.05 mg

price1 :

160 USD

size2 :

0.1 mg

price2 :

235

more info or order :

MyBioSource product webpage