catalog number :
MBS7000024
products full name :
lasA Antibody
products short name :
[lasA]
products name syn :
[Protease LasA; Staphylolytic protease; lasA; PA1871]
other names :
[protease LasA; Protease LasA; Staphylolytic protease]
products gene name :
[lasA]
other gene names :
[lasA]
uniprot entry name :
LASA_PSEAE
reactivity :
Pseudomonas aeruginosa
purity :
>95%,Protein G purified
storage stability :
Shipped at 4 degree C. Upon delivery, aliquot and store at -20 degree C or -80 degree C.
tested application :
ELISA (EIA)
other info1 :
Immunogen: Recombinant Pseudomonas aeruginosa Protease LasA protein
other info2 :
Conjugation: Non-conjugated. Storage Buffer: Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
products description :
Involved in proteolysis and elastolysis (degradation of the host protein elastin). Has staphylolytic activity (degrades pentaglycine cross-links in cell wall peptidogylcan), preferring Gly-Gly- -X substrates where X is Ala or Gly (PubMed:11179971). Enhances the elastolytic but not proteolytic activity of elastase (lasB) and elastolytic activity of other proteases (PubMed:2110137). Degradation of host elastin is likely to contribute to the pathogenicity of P.aeruginosa. While either His-317 or His-356 can abstract a proton in the hydrolysis reaction, the same residue performs both functions in a given catalytic cycle, with the other stabilizing the catalytic intermediate (PubMed:20026068).
ncbi acc num :
NP_250562.1
ncbi gb acc num :
NC_002516.2
ncbi mol weight :
45,517 Da
uniprot summary :
Involved in proteolysis and elastolysis (degradation of the host protein elastin). Has staphylolytic activity (degrades pentaglycine cross-links in cell wall peptidogylcan), preferring Gly-Gly- -X substrates where X is Ala or Gly (PubMed:11179971). Enhances the elastolytic but not proteolytic activity of elastase (lasB) and elastolytic activity of other proteases (PubMed:2110137). Degradation of host elastin is likely to contribute to the pathogenicity of P.aeruginosa. While either His-317 or His-356 can abstract a proton in the hydrolysis reaction, the same residue performs both functions in a given catalytic cycle, with the other stabilizing the catalytic intermediate (PubMed:20026068).