protein

Murine BCA-1 / BLC (CXCL13)

MBS696188

0.005 mg

125 USD

Recombinant Protein

Murine BCA-1 / BLC (CXCL13)

[BCA-1 / BLC]

[B cell Attracting Chemokine-1, CXCL 13, BLC (mouse),BLR1 Ligand]

[C-X-C motif chemokine 13; C-X-C motif chemokine 13; C-X-C motif chemokine 13; CXC chemokine BLC; B lymphocyte chemoattractant; small-inducible cytokine B13; small inducible cytokine subfamily B (Cys-X-Cys), member 13; chemokine (C-X-C motif) ligand 13; B lymphocyte chemoattractant; CXC chemokine BLC; Small-inducible cytokine B13]

[BCA-1]

[BLC]

[Cxcl13; Cxcl13; BLC; Angie; BCA-1; BLR1L; ANGIE2; Scyb13; 4631412M08Rik; Blc; Scyb13]

CXL13_MOUSE

Species Reactivity: Mouse

ILEAHYTNLK CRCSGVISTV VGLNIIDRIQ VTPPGNGCPK TEVVIWTKMK KVICVNPRAK WLQRLLRHVQ SKSLSSTPQA PVSKRRAA

>=98% by SDS-PAGE gel and HPLC analyses.

Sterile filtered through a 0.2 micron filter. Lyophilized with no additives.

At -20 degree C

Source: E. coli. Biological Activity: Determined by its ability to chemoattract murine B cells using a concentration of 10.0-100.0 ng/ml. Protein Content: Verified by UV Spectroscopy and/or SDS-PAGE gel. Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (<1 EU/ug). Authenticity: Verified by N-terminal and Mass Spectrometry analyses (when applicable).

Cell Type: B Cells, Monocytes and Macrophages, T Cells. Reconstitution: Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8 degree C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1 % BSA) and store in working aliquots at -20 degree C to -80 degree C. Country of Origin: USA

Immunology; Chemotaxis

BCA-1/BLC, a CXC chemokine, is expressed in the liver, spleen, lymph nodes, appendix and stomach. It exerts its activities through its only receptor CXCR5. BCA-1/BLC is a potent chemoattractant for B lymphocytes and induces weak chemotactic response in T cells and macrophages. It manifests no activity on neutrophils and monocytes. Recombinant murine BLC is a 9.8 kDa protein containing 88 amino acid residues including the four highly conserved cysteine residues present in CXC chemokines.

7673946

O55038.1

O55038

Chemokine Receptors Bind Chemokines Pathway (1000944); Chemokine Signaling Pathway (99271); Chemokine Signaling Pathway (672435); Chemokine Signaling Pathway (96864); Class A/1 (Rhodopsin-like Receptors) Pathway (1000942); Cytokine-cytokine Receptor Interaction Pathway (83248); Cytokine-cytokine Receptor Interaction Pathway (460); G Alpha (i) Signalling Events Pathway (1000973); GPCR Downstream Signaling Pathway (1000971); GPCR Ligand Binding Pathway (1000941)

CXCL13: Chemotactic for B-lymphocytes but not for T-lymphocytes, monocytes and neutrophils. Does not induce calcium release in B- lymphocytes. Binds to BLR1/CXCR5. Belongs to the intercrine alpha (chemokine CxC) family. Protein type: Secreted; Motility/polarity/chemotaxis; Secreted, signal peptide. Cellular Component: extracellular space; cell; extracellular region; cytosol. Molecular Function: heparin binding; fibroblast growth factor binding; CXCR3 chemokine receptor binding; chemokine activity; protein heterodimerization activity; CXCR5 chemokine receptor binding; CCR10 chemokine receptor binding; cytokine activity; receptor agonist activity. Biological Process: lymphocyte chemotaxis across high endothelial venule; response to lipopolysaccharide; positive regulation of leukocyte chemotaxis; chemotaxis; positive regulation of cell-cell adhesion mediated by integrin; positive regulation of integrin activation; lymph node development; regulation of cell proliferation; G-protein coupled receptor protein signaling pathway; elevation of cytosolic calcium ion concentration; cell surface receptor linked signal transduction; cell-cell signaling; defense response to bacterium; immune response; inflammatory response

0.005 mg

125 USD

0.02 mg

195

0.1 mg

505

0.5 mg

1410

1 mg

2320