Human IL-8 (72 a.a.) (CXCL8) | MyBioSource MBS696053 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Human IL-8 (72 a.a.) (CXCL8)

catalog :

MBS696053

quantity :

0.005 mg

price :

125 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS696053

products type :

Recombinant Protein

products full name :

Human IL-8 (72 a.a.) (CXCL8)

products short name :

[IL-8]

products name syn :

[Recombinant Human IL-8 (72 a.a.) (CXCL8)]

other names :

[Interleukin-8; Interleukin-8; interleukin-8; emoctakin; interleukin 8; T-cell chemotactic factor; neutrophil-activating peptide 1; beta-thromboglobulin-like protein; granulocyte chemotactic protein 1; tumor necrosis factor-induced gene 1; alveolar macrophage chemotactic factor I; monocyte-derived neutrophil chemotactic factor; monocyte-derived neutrophil-activating peptide; small inducible cytokine subfamily B, member 8; lymphocyte derived neutrophil activating peptide; lung giant cell carcinoma-derived chemotactic protein; beta endothelial cell-derived neutrophil activating peptide; chemokine (C-X-C motif) ligand 8; C-X-C motif chemokine 8; Chemokine (C-X-C motif) ligand 8; Emoctakin; Granulocyte chemotactic protein 1; GCP-1; Monocyte-derived neutrophil chemotactic factor; MDNCF; Monocyte-derived neutrophil-activating peptide; MONAP; Neutrophil-activating protein 1; NAP-1; Protein 3-10C; T-cell chemotactic factorCleaved into the following 7 chains:MDNCF-aAlternative name(s):GCP/IL-8 protein IV; IL8/NAP1 form I]

products gene name :

[IL-8]

products gene name syn :

[CXCL8]

other gene names :

[CXCL8; CXCL8; IL8; NAF; GCP1; LECT; LUCT; NAP1; GCP-1; LYNAP; MDNCF; MONAP; NAP-1; IL8; IL-8; GCP-1; MDNCF; MONAP; NAP-1; LYNAP; NAF]

uniprot entry name :

IL8_HUMAN

host :

E Coli

reactivity :

Species Reactivity: Human. Cross Reactivity: Bacteria, Monkey, Mouse, Rat

sequence :

SAKELRCQC IKTYSKPFH PKFIKELRV IESGPHCAN TEIIVKLSD GRELCLDPK ENWVQRVVE KFLKRAENS

purity :

Above 98% as determined by SDS-PAGE Analysis.

storage stability :

At -20 degree C

other info1 :

Biological Activity: Determined by its ability to chemoattract human peripheral blood neutrophils using a concentration range of 10.0-100.0 ng/ml.

other info2 :

Cell Type: Monocytes and Macrophages, Endothelial Cells

products categories :

Apoptosis; Angiogenesis; Neurosciences; Inflammation; Chemotaxis

products description :

IL-8 is a proinflammatory CXC chemokine that can signal through the CXCR1 and CXCR2 receptors. It is secreted by monocytes and endothelial cells. IL-8 chemoattracts and activates neutrophils. Recombinant human IL-8 (monocyte-derived) is an 8.4 kDa protein containing 72 amino acid residues.

ncbi gi num :

124359

ncbi acc num :

P10145.1

uniprot acc num :

P10145

ncbi mol weight :

11,338 Da

ncbi pathways :

ATF-2 Transcription Factor Network Pathway (138006); ATF4 Activates Genes Pathway (530772); Amoebiasis Pathway (167324); Amoebiasis Pathway (167191); Bladder Cancer Pathway (83115); Bladder Cancer Pathway (527); Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway (137993); Cellular Senescence Pathway (905991); Cellular Responses To Stress Pathway (645258); Chagas Disease (American Trypanosomiasis) Pathway (147809)

ncbi summary :

The protein encoded by this gene is a member of the CXC chemokine family. This chemokine is one of the major mediators of the inflammatory response. This chemokine is secreted by several cell types. It functions as a chemoattractant, and is also a potent angiogenic factor. This gene is believed to play a role in the pathogenesis of bronchiolitis, a common respiratory tract disease caused by viral infection. This gene and other ten members of the CXC chemokine gene family form a chemokine gene cluster in a region mapped to chromosome 4q. [provided by RefSeq, Jul 2008]

uniprot summary :

IL8: IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus. IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity on neutrophil activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to IL-8(1-77), respectively. Belongs to the intercrine alpha (chemokine CxC) family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Secreted; Secreted, signal peptide; Cytokine; Motility/polarity/chemotaxis. Chromosomal Location of Human Ortholog: 4q13-q21. Cellular Component: extracellular space; extracellular region. Molecular Function: protein binding; chemokine activity; interleukin-8 receptor binding. Biological Process: regulation of cell adhesion; neutrophil chemotaxis; neutrophil activation; negative regulation of G-protein coupled receptor protein signaling pathway; unfolded protein response; calcium-mediated signaling; chemotaxis; signal transduction; regulation of retroviral genome replication; induction of positive chemotaxis; negative regulation of cell proliferation; G-protein coupled receptor protein signaling pathway; cellular protein metabolic process; unfolded protein response, activation of signaling protein activity; receptor internalization; response to molecule of bacterial origin; immune response; angiogenesis; cell motility; cell cycle arrest; inflammatory response; embryonic gut development

size1 :

0.005 mg

price1 :

125 USD

size2 :

0.025 mg

price2 :

195

size3 :

0.1 mg

price3 :

505

size4 :

0.5 mg

price4 :

1410

size5 :

1 mg

price5 :

2320

more info or order :

MyBioSource product webpage