protein

Human IGF-BP2

MBS696052

0.005 mg

125 USD

Recombinant Protein

Human IGF-BP2

IGF-BP2

Recombinant Human IGF-BP2

Insulin-like growth factor-binding protein 2; Insulin-like growth factor-binding protein 2; insulin-like growth factor-binding protein 2; IBP-2; IGFBP-2; IGF-binding protein 2; insulin-like growth factor binding protein 2, 36kDa

IGF-BP2

IGFBP2; IGFBP2; IBP2; IGF-BP53; BP2; IBP2; IBP-2; IGF-binding protein 2; IGFBP-2

IBP2_HUMAN

(BTI-Tn-5B1-4) Hi-5 Insect cells*

Species Reactivity: Human. Cross Reactivity: Mouse

EVLFRCPPC TPERLAACG PPPVAPPAA VAAVAGGAR MPCAELVRE PGCGCCSVC ARLEGEACQ VYTPRCGQG LRCYPHPGS ELPLQALVM GEGTCEKRR DAEYGASPE QVADNGDDH SEGGLVENH VDSTMNMLG GGGSAGRKP LKSGMKELA VFREKVTEQ HRQMGKGGK HHLGLEEPK KLRPPPART PCQQELDQV LERISTMRL PDERGPLEH LYSLHIPNC DKHGLYNLK QCKMSLNGQ RGECWCVNP NTGKLIQGA PTIRGDPEC HLFYNEQQE ARGVHTQRM Q

Above 98% as determined by SDS-PAGE Analysis.

At -20 degree C

Biological Activity: Determined by its ability to inhibit IGF-I induced proliferation of FDC-P1 cells.

Cell Type: Stem Cells

Stem Cell Research; Apoptosis; Cancer; Proliferation and Cell Cycle; Metabolic Regulation and Diabetes

IGF-BPs controls the distribution, function and activity of IGFs in various cell tissues and body fluids. Currently there are seven named IGF-BPs that form high affinity complexes with both IGF-I and IGF-II. IGF-BP2 is a cysteine-rich secreted protein produced by bone cells, and is most abundant in the brain. IGF-BP2 has been shown to inhibit IGF-II action in human breast and ovarian carcinoma cells. Recombinant human IGF-BP2 is a 31.5 kDa protein consisting of 289 amino acid residues including the IGF-BP domain and thyroglobulin type-I domain. *Manufactured using (BTI-Tn-5B1-4) cells under license from the Boyce Thompson Institute for Plant Research, Inc.

290457647

P18065.2

P18065

34,814 Da

Metabolism Of Proteins Pathway (106230); Myometrial Relaxation And Contraction Pathways (198759); Regulation Of Insulin-like Growth Factor (IGF) Transport And Uptake By Insulin-like Growth Factor Binding Proteins (IGFBPs) Pathway (105908)

IGFBP2: Inhibits IGF-mediated growth and developmental rates. IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Binds IGF2 more than IGF1. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 2q35. Cellular Component: extracellular space; apical plasma membrane; extracellular region; cytoplasmic vesicle. Molecular Function: protein binding; insulin-like growth factor I binding; insulin-like growth factor II binding. Biological Process: response to drug; regulation of insulin-like growth factor receptor signaling pathway; response to retinoic acid; response to lithium ion; response to glucocorticoid stimulus; female pregnancy; positive regulation of activated T cell proliferation; signal transduction; response to estradiol stimulus; cellular response to hormone stimulus; cellular protein metabolic process; response to mechanical stimulus; regulation of cell growth; response to nutrient; aging

0.005 mg

125 USD

0.02 mg

195

0.1 mg

690

0.5 mg

2410

1 mg

3960