protein

Human ENA-78 / CXCL5 (8-78 a.a.)

MBS695999

0.005 mg

125 USD

Recombinant Protein

Human ENA-78 / CXCL5 (8-78 a.a.)

[ENA-78 / CXCL5]

[Recombinant Human ENA-78 (CXCL5) (8-78 a.a.)]

[C-X-C motif chemokine 5; C-X-C motif chemokine 5; C-X-C motif chemokine 5; neutrophil-activating protein 78; neutrophil-activating peptide ENA-78; epithelial-derived neutrophil-activating protein 78; small inducible cytokine subfamily B (Cys-X-Cys), member 5 (epithelial-derived neutrophil-activating peptide 78); chemokine (C-X-C motif) ligand 5; ENA-78(1-78); Epithelial-derived neutrophil-activating protein 78; Neutrophil-activating peptide ENA-78; Small-inducible cytokine B5Cleaved into the following 2 chains:ENA-78(8-78); ENA-78(9-78)]

[ENA-78]

[CXCL5]

[CXCL5; CXCL5; SCYB5; ENA-78; ENA78; SCYB5]

CXCL5_HUMAN

E Coli

Species Reactivity: Human

LRELRCVCL QTTQGVHPK MISNLQVFA IGPQCSKVE VVASLKNGK EICLDPEAP FLKKVIQKI LDGGNKEN

Above 98% as determined by SDS-PAGE Analysis.

At -20 degree C

Biological Activity: Determined by its ability to chemoattract human neutrophils using a concentration range of 10.0-100.0 ng/ml.

Cell Type: Monocytes and Macrophages, Endothelial Cells

Angiogenesis; Inflammation; Chemotaxis

ENA-78 is a CXC chemokine that signals through the CXCR2 receptor. It is expressed in monocytes, platelets, endothelial cells, and mast cells. ENA-78 is a chemoattractant for neutrophils. Three N-terminal truncated variants of human ENA-78; ENA 5-78, ENA 8-78, ENA 9-78, contain 74, 71, and 70 amino acid residues, respectively, possess increased biological activity. ENA-78 contains the four conserved cysteine residues present in CXC chemokines, and also contains the ELR' motif common to CXC chemokine that bind to the CXCR1 and CXCR2 receptors. Recombinant human ENA-78 is a 7.8 kDa protein consisting of 71 amino acid residues.

1169525

P42830.1

P42830

11,972 Da

Chemokine Receptors Bind Chemokines Pathway (106359); Chemokine Signaling Pathway (99051); Chemokine Signaling Pathway (96864); Class A/1 (Rhodopsin-like Receptors) Pathway (106357); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); G Alpha (i) Signalling Events Pathway (119550); GPCR Downstream Signaling Pathway (119548); GPCR Ligand Binding Pathway (161020); Peptide Ligand-binding Receptors Pathway (106358)

This gene encodes a protein that is a member of the CXC subfamily of chemokines. Chemokines, which recruit and activate leukocytes, are classified by function (inflammatory or homeostatic) or by structure. This protein is proposed to bind the G-protein coupled receptor chemokine (C-X-C motif) receptor 2 to recruit neutrophils, to promote angiogenesis and to remodel connective tissues. This protein is thought to play a role in cancer cell proliferation, migration, and invasion. [provided by RefSeq, May 2013]

CXCL5: Involved in neutrophil activation. In vitro, ENA-78(8- 78) and ENA-78(9-78) show a threefold higher chemotactic activity for neutrophil granulocytes. Belongs to the intercrine alpha (chemokine CxC) family. Protein type: Secreted, signal peptide; Motility/polarity/chemotaxis; Secreted. Chromosomal Location of Human Ortholog: 4q13.3. Cellular Component: extracellular space; extracellular region. Molecular Function: chemokine activity; CXCR chemokine receptor binding. Biological Process: G-protein coupled receptor protein signaling pathway; cell-cell signaling; positive regulation of cell proliferation; neutrophil mediated immunity; response to lipopolysaccharide; positive regulation of leukocyte chemotaxis; immune response; signal transduction; chemotaxis; inflammatory response

0.005 mg

125 USD

0.02 mg

195

0.1 mg

505

0.5 mg

1410

1 mg

2320