product summary
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company name :
MyBioSource
product type :
protein
product name :
Human GDF-11
catalog :
MBS695875
quantity :
0.005 mg
price :
125 USD
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS695875
products type :
Recombinant Protein
products full name :
Human GDF-11
products short name :
GDF-11
products name syn :
Recombinant Human GDF-11
other names :
Growth/differentiation factor 11; Growth/differentiation factor 11; growth/differentiation factor 11; GDF-11; bone morphogenetic protein 11; growth differentiation factor 11; Bone morphogenetic protein 11; BMP-11
products gene name :
GDF-11
other gene names :
GDF11; GDF11; BMP11; BMP-11; BMP11; GDF-11; BMP-11
uniprot entry name :
GDF11_HUMAN
host :
E Coli
reactivity :
Species Reactivity: Human. Cross Reactivity: Mouse
sequence :
NLGLDCDEH SSESRCCRY PLTVDFEAF GWDWIIAPK RYKANYCSG QCEYMFMQK YPHTHLVQQ ANPRGSAGP CCTPTKMSP INMLYFNDK QQIIYGKIP GMVVDRCGC S
purity :
Above 98% as determined by SDS-PAGE Analysis.
storage stability :
At -20 degree C
other info1 :
Biological Activity: The ED50 was determined by its ability to inhibit induced alkaline phosphatase production by ATDC-5 chondrogenic cells. The expected ED50 for this effect is 0.08-0.10 ug/ml.
other info2 :
Cell Type: Neurons
products categories :
Stem Cell Research; Neurosciences
products description :
GDF-11 is a myostatin-homologous protein that acts as an inhibitor of nerve tissue growth. GDF-11 has been shown to suppress neurogenesis through a myostatin-like pathway, which involves arrest of progenitor cell-cycle in the G1 phase. Similarities between myostatin and GDF-11, which are 90% identical in their amino acid sequence, suggests that the regulatory mechanisms responsible for maintaining proper tissue size during neural and muscular development might be the same. Recombinant human GDF-11 is a 25.0 kDa disulfide-linked homodimer containing two 109 amino acid polypeptide chains. It is highly homologous to myostatin/GDF-8 sharing 90% amino-acid sequence identity.
ncbi gi num :
12643335
ncbi acc num :
O95390.1
uniprot acc num :
O95390
ncbi summary :
The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in mice and Xenopus suggest that this protein is involved in mesodermal formation and neurogenesis during embryonic development. [provided by RefSeq, Jul 2008]
uniprot summary :
GDF11: Secreted signal that acts globally to specify positional identity along the anterior/posterior axis during development. Play critical roles in patterning both mesodermal and neural tissues and in establishing the skeletal pattern. Belongs to the TGF-beta family. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 12q13.2. Cellular Component: extracellular space. Molecular Function: growth factor activity; cytokine activity; transforming growth factor beta receptor binding. Biological Process: nervous system development; cell maturation; palate development; regulation of apoptosis; negative regulation of cell proliferation; negative regulation of cell differentiation; camera-type eye morphogenesis; spinal cord anterior/posterior patterning; ureteric bud development; regulation of MAPKKK cascade; pancreas development; mesoderm development; skeletal development; cell development; metanephros development; growth
size1 :
0.005 mg
price1 :
125 USD
size2 :
0.02 mg
price2 :
195
size3 :
0.1 mg
price3 :
640
size4 :
0.5 mg
price4 :
1820
size5 :
1 mg
price5 :
2980
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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