protein

Human FGF-10

MBS695834

0.005 mg

125 USD

Recombinant Protein

Human FGF-10

[FGF-10]

[Fibroblast Growth Factor-10, FGFA, Keratinocyte growth factor-2]

[Fibroblast growth factor 10; Fibroblast growth factor 10; fibroblast growth factor 10; FGF-10; keratinocyte growth factor 2; produced by fibroblasts of urinary bladder lamina propria; fibroblast growth factor 10; Keratinocyte growth factor 2]

[FGF-10]

[FGF10; FGF10; FGF-10]

FGF10_HUMAN

MLGQDMVSP EATNSSSSS FSSPSSAGR HVRSYNHLQ GDVRWRKLF SFTKYFLKI EKNGKVSGT KKENCPYSI LEITSVEIG VVAVKAINS NYYLAMNKK GKLYGSKEF NNDCKLKER IEENGYNTY ASFNWQHNG RQMYVALNG KGAPRRGQK TRRKNTSAH FLPMVVHS

>= 95% by SDS-PAGE and HPLC analyses

Sterile filtered through a 0.2 micron filter. Lyophilized fron 5mM Sodium Phosphate pH 7.4 + 80 mM NaCl

Store at -20 degree C

Testing Data

Authenticity: Verified by N-terminal and Mass Spectrometry analyses (when applicable). Endotoxin: Endotoxin level is 50 is = 2 x 10 6 units/mg. Reconstitution: Centrifuge the vial prior to opening. Reconstitute in 5mM Sodium Phosphate, pH 7.4 to a concentration of 0.1-1.0 mg/ml. Do not vortex. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20 degree C to -80 degree C. Country of Origin: USA.

Stem Cell Research; Angiogenesis; Proliferation and Cell Cycle

FGF-10 is a heparin binding growth factor that belongs to the FGF family. Proteins of this family play a central role during prenatal development and postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. FGF-10 is most related to KGF/FGF-7 and is expressed during the development and preferentially in adult lungs. It signals through the FGFR 2b. Recombinant human FGF-10 is a 19.3 kDa protein consisting of 170 amino acid residues.

6015141

O15520.1

O15520

Activated Point Mutants Of FGFR2 Pathway (645281); Adaptive Immune System Pathway (366160); Constitutive PI3K/AKT Signaling In Cancer Pathway (685535); DAP12 Interactions Pathway (685549); DAP12 Signaling Pathway (685550); Developmental Biology Pathway (477129); Disease Pathway (530764); Downstream Signal Transduction Pathway (106385); Downstream Signaling Events Of B Cell Receptor (BCR) Pathway (576250); Downstream Signaling Of Activated FGFR Pathway (160957)

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein exhibits mitogenic activity for keratinizing epidermal cells, but essentially no activity for fibroblasts, which is similar to the biological activity of FGF7. Studies of the mouse homolog of suggested that this gene is required for embryonic epidermal morphogenesis including brain development, lung morphogenesis, and initiation of lim bud formation. This gene is also implicated to be a primary factor in the process of wound healing. [provided by RefSeq, Jul 2008]

FGF10: Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. May play a role in wound healing. Interacts with FGFR1 and FGFR2. Interacts with FGFBP1. Belongs to the heparin-binding growth factors family. Protein type: Cytokine; Secreted, signal peptide; Secreted; Motility/polarity/chemotaxis; Cell development/differentiation. Chromosomal Location of Human Ortholog: 5p13-p12. Cellular Component: extracellular matrix; extracellular space; cell surface; extracellular region; plasma membrane; nucleus. Molecular Function: heparin binding; protein binding; growth factor activity; type 2 fibroblast growth factor receptor binding; chemoattractant activity; fibroblast growth factor receptor binding. Biological Process: salivary gland development; nerve growth factor receptor signaling pathway; somatic stem cell maintenance; activation of MAPK activity; urothelial cell proliferation; positive regulation of epithelial cell proliferation involved in wound healing; positive regulation of transcription, DNA-dependent; muscle cell fate commitment; response to lipopolysaccharide; regulation of saliva secretion; embryonic pattern specification; G1/S-specific positive regulation of cyclin-dependent protein kinase activity; epithelial cell proliferation; positive regulation of fibroblast proliferation; positive chemotaxis; embryonic digestive tract morphogenesis; induction of an organ; mesonephros development; embryonic genitalia morphogenesis; spleen development; positive regulation of keratinocyte migration; fibroblast growth factor receptor signaling pathway; positive regulation of DNA repair; positive regulation of urothelial cell proliferation; positive regulation of peptidyl-tyrosine phosphorylation; branching morphogenesis of a tube; smooth muscle cell differentiation; positive regulation of transcription from RNA polymerase II promoter; determination of left/right symmetry; metanephros development; positive regulation of epithelial cell proliferation; wound healing; radial glial cell differentiation; positive regulation of mitotic cell cycle; response to estradiol stimulus; positive regulation of vascular endothelial growth factor receptor signaling pathway; induction of positive chemotaxis; negative regulation of cell proliferation; establishment of mitotic spindle orientation; positive regulation of MAPKKK cascade; tissue regeneration; positive regulation of lymphocyte proliferation; pancreas development; male genitalia morphogenesis; thyroid gland development; lacrimal gland development; angiogenesis; otic vesicle formation; female genitalia morphogenesis; positive regulation of Notch signaling pathway; epidermal growth factor receptor signaling pathway; hair follicle morphogenesis; phosphoinositide-mediated signaling; thymus development; keratinocyte proliferation; regulation of activin receptor signaling pathway; embryonic camera-type eye development; odontogenesis of dentine-containing teeth; limb bud formation; positive regulation of ATPase activity; pituitary gland development; actin cytoskeleton reorganization; white fat cell differentiation; insulin receptor signaling pathway; innate immune response; blood vessel remodeling; positive regulation of Ras protein signal transduction; positive regulation of DNA replication; regulation of smoothened signaling pathway. Disease: Lacrimoauriculodentodigital Syndrome; Aplasia Of Lacrimal And Salivary Glands

0.005 mg

125 USD

0.025 mg

195

0.1 mg

505

0.5 mg

1410

1 mg

2320