Human sTRAIL Receptror-2 (DR5) | MyBioSource MBS695823 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Human sTRAIL Receptror-2 (DR5)

catalog :

MBS695823

quantity :

0.01 mg

price :

125 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS695823

products type :

Recombinant Protein

products full name :

Human sTRAIL Receptror-2 (DR5)

products short name :

[sTRAIL Receptror-2]

products name syn :

[Recombinant Human sTRAIL Receptor-2, soluble TRAIL Receptor-2,dr5,TNFRSF10B,KILER,TRICK2A,TRICKB]

other names :

[Tumor necrosis factor receptor superfamily member 10B; Tumor necrosis factor receptor superfamily member 10B; tumor necrosis factor receptor superfamily member 10B; Fas-like protein; death receptor 5; cytotoxic TRAIL receptor-2; TNF receptor superfamily member 10b; apoptosis inducing receptor TRAIL-R2; apoptosis inducing protein TRICK2A/2B; TNF-related apoptosis-inducing ligand receptor 2; death domain containing receptor for TRAIL/Apo-2L; tumor necrosis factor receptor-like protein ZTNFR9; p53-regulated DNA damage-inducible cell death receptor(killer); tumor necrosis factor receptor superfamily, member 10b; Death receptor 5; TNF-related apoptosis-inducing ligand receptor 2; TRAIL receptor 2; TRAIL-R2; CD_antigen: CD262]

products gene name :

[sTRAIL]

other gene names :

[TNFRSF10B; TNFRSF10B; DR5; CD262; KILLER; TRICK2; TRICKB; ZTNFR9; TRAILR2; TRICK2A; TRICK2B; TRAIL-R2; KILLER/DR5; DR5; KILLER; TRAILR2; TRICK2; ZTNFR9; TRAIL receptor 2; TRAIL-R2]

uniprot entry name :

TR10B_HUMAN

host :

E Coli

reactivity :

Species Reactivity: Human

sequence :

MESALITQQD LAPQQRVAPQ QKRSSPSEGL CPPGHHISED GRDCISSCKYG QDYSTHWNDL. LFCLRCRTCD SGEVELSPCT RRRNTVCQCE EGTFREEDSP EMCRKCRTGC PRGMVKVGDC . TPWSDIECVH KES

purity :

>=98% as determined by SDS-PAGE gel and HPLC analyses.

form :

Sterile filtered through a 0.2 micron filter. Lyophilized with no additives.

storage stability :

At -20°C

other info1 :

. Authenticity: Verufied by N-terminal and Mass Spectometry analyses(when applicable). Endotoxin: Endotoxin level is<0.1 ng/ug of protein(<1EU/ug). Protein Content: Verified by UV Spectroscopy and/or SDS-PAGE gel. Biological activity: Determined by its ability to inhibit apoptosis induced by Human sTRAIL/Apo2L in LN-18 cells(glioblastoma cells).

other info2 :

. Reconstitution: Centrifuge the vial prior to opening.Reconstitute in water to a concentration of 0.1-1.0 mg/mL. Do not vortex.For extended storage, it is recommended to further dilute in a buffer containing a carrier protein(example 0.1% BSA)and store in working aliquots at -20°C to -80°C.

products categories :

Apoptosis; Receptors

products description :

TRAIL Receptor-1/DR4 and TRAIL Receptor-2/DR5 belong to the TNFR superfamily of transmembrane proteins and contain a cytoplasmic "death domain", which can activate the cell's apoptotic machinery. These receptors are activated by binding to either membrane anchored or soluble TRAIL/Apo2L. Recombinant human soluble TRAIL Receptor-2/DR5 is a 14.9 kDa protein (133 amino acid residues) consisting of the TNFR homologous, cysteine rich portion of the extracellular domain.

ncbi gi num :

313104032

ncbi acc num :

O14763.2

uniprot acc num :

O14763

ncbi pathways :

Apoptosis Pathway (198797); Apoptosis Pathway (83060); Apoptosis Pathway (470); Apoptosis Pathway (105648); Apoptosis Modulation And Signaling Pathway (198822); Caspase-8 Activation By Cleavage Pathway (105654); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); DNA Damage Response Pathway (198788); Death Receptor Signalling Pathway (105650)

ncbi summary :

The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene. [provided by RefSeq, Mar 2009]

uniprot summary :

TRAIL-R2: Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF- kappa-B. Homotrimer. Can interact with TRADD and RIPK1. Regulated by p53/TP53. Widely expressed in adult and fetal tissues; very highly expressed in tumor cell lines such as HeLaS3, K-562, HL-60, SW480, A-549 and G-361; highly expressed in heart, peripheral blood lymphocytes, liver, pancreas, spleen, thymus, prostate, ovary, uterus, placenta, testis, esophagus, stomach and throughout the intestinal tract; not detectable in brain. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Motility/polarity/chemotaxis; Membrane protein, integral. Chromosomal Location of Human Ortholog: 8p22-p21. Cellular Component: integral to membrane; plasma membrane. Molecular Function: protein binding; TRAIL binding; receptor activity. Biological Process: regulation of apoptosis; caspase activation; cell surface receptor linked signal transduction; positive regulation of I-kappaB kinase/NF-kappaB cascade; induction of apoptosis via death domain receptors; apoptosis; activation of NF-kappaB-inducing kinase. Disease: Squamous Cell Carcinoma, Head And Neck

size1 :

0.01 mg

price1 :

125 USD

size2 :

0.05 mg

price2 :

195

size3 :

0.1 mg

price3 :

275

size4 :

0.5 mg

price4 :

730

size5 :

1 mg

price5 :

1180

more info or order :

MyBioSource product webpage