Human sTRAIL Receptror-1 (DR4) | MyBioSource MBS695740 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Human sTRAIL Receptror-1 (DR4)

catalog :

MBS695740

quantity :

0.01 mg

price :

125 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS695740

products type :

Recombinant Protein

products full name :

Human sTRAIL Receptror-1 (DR4)

products short name :

[sTRAIL Receptror-1]

products name syn :

[soluble TRAIL Receptor-1, DR4, TNFRSDF10A,Apo2]

other names :

[Tumor necrosis factor receptor superfamily member 10A; Tumor necrosis factor receptor superfamily member 10A; tumor necrosis factor receptor superfamily member 10A; TRAIL-R1; TRAIL receptor 1; death receptor 4; cytotoxic TRAIL receptor; TNF-related apoptosis-inducing ligand receptor 1; tumor necrosis factor receptor superfamily member 10a variant 2; tumor necrosis factor receptor superfamily, member 10a; Death receptor 4; TNF-related apoptosis-inducing ligand receptor 1; TRAIL receptor 1; TRAIL-R1; CD_antigen: CD261]

products gene name :

[sTRAIL]

other gene names :

[TNFRSF10A; TNFRSF10A; DR4; APO2; CD261; TRAILR1; TRAILR-1; APO2; DR4; TRAILR1; TRAIL receptor 1; TRAIL-R1]

uniprot entry name :

TR10A_HUMAN

reactivity :

Species Reactivity: Human

sequence positions :

[SGTGAAAATP SKVWGSSAGR IEPRGGGRGA LPTSMGQHGP SARARAGRAP GPRPAREASP RLRVHKTFKF VVVGVLLQVV PSSAATIKLH DQSIGTQQWE HSPLGELCPP GSHRSERPGA CNRCTEGVGY TNASQQLFAC LPCTACKSDE EERSPCTTTR NTACQCKPGT FRNDNSAEMC RKCSTGCPRG MVKVKDCTPW SDIECVHKES GNGHN]

purity :

>=98% as determined by SDS-PAGE gel and HPLC analyses.

form :

Sterile filtered through a 0.2 micron filter. Lyophilized with no additives.

storage stability :

At -20°C

other info1 :

. Source: E. coli . Biological Activity: Measured by its ability to inhibit apoptosis in LN-18 cells. The expected ED 50 for this effect is 0.4 -0.5 ug/ml.

other info2 :

. Authencity: Verified by N-terminal and Mass Spectrometry analyses(when applicable). Endotoxin: Endotoxin level is <0.1 ng/ug of protein (<1EU/ug). Protein Content: Verified by UV Sprectroscopy and /or SDS-PAGE gel. Reconstitution: Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0mg/mL.Do not vortex.For extended storage,it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.

products categories :

Receptors

products description :

TRAIL Receptor-1/DR4 and TRAIL Receptor-2/DR5 belong to the TNFR superfamily of transmembrane proteins and contain a cytoplasmic "death domain, " which can activate the cell's apoptotic machinery. These receptors are activated by binding to either membrane anchored or soluble TRAIL/Apo2L. Recombinant human soluble TRAIL Receptor-1/DR4 is a 22.7 kDa protein (215 amino acid residues) consisting of the TNFR homologous, cysteine rich portion of the extracellular domain.

ncbi gi num :

313104273

ncbi acc num :

O00220.3

uniprot acc num :

O00220

ncbi pathways :

Apoptosis Pathway (83060); Apoptosis Pathway (470); Apoptosis Modulation And Signaling Pathway (198822); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); Direct P53 Effectors Pathway (137939); Influenza A Pathway (217173); Influenza A Pathway (217150); Kit Receptor Signaling Pathway (198826); Measles Pathway (213306)

ncbi summary :

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. [provided by RefSeq, Jul 2008]

uniprot summary :

TRAIL-R1: Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF- kappa-B. Protein type: Membrane protein, integral. Chromosomal Location of Human Ortholog: 8p21. Cellular Component: plasma membrane; integral to membrane. Molecular Function: protein binding; protease binding; death receptor activity; TRAIL binding; receptor activity; transcription factor binding. Biological Process: caspase activation; induction of apoptosis via death domain receptors; apoptosis; activation of NF-kappaB-inducing kinase; signal transduction

size1 :

0.01 mg

price1 :

125 USD

size2 :

0.05 mg

price2 :

195

size3 :

0.1 mg

price3 :

275

size4 :

0.5 mg

price4 :

730

size5 :

1 mg

price5 :

1180

more info or order :

MyBioSource product webpage