protein

Murine Lungkine (CXCL15)

MBS695723

0.005 mg

125 USD

Recombinant Protein

Murine Lungkine (CXCL15)

[Lungkine]

[Recombinant Murine Lungkine (CXCL15)]

[C-X-C motif chemokine 15; C-X-C motif chemokine 15; C-X-C motif chemokine 15; interleukin 8; small-inducible cytokine B15; small inducible cytokine subfamily B, member 15; chemokine (C-X-C motif) ligand 15; Lungkine; Small-inducible cytokine B15]

[CXCL15]

[Cxcl15; Cxcl15; Il8; weche; Scyb15; lungkine; Scyb15]

CXL15_MOUSE

E Coli

Species Reactivity: Mouse. Cross Reactivity: Human

QELRCLCIQ EHSEFIPLK LIKNIMVIF ETIYCNRKE VIAVPKNGS MICLDPDAP WVKATVGPI TNRFLPEDL KQKEFPPAM KLLYSVEHE KPLYLSFGR PENKRIFPF PIRETSRHF ADLAHNSDR NFLRDSSEV SLTGSDA

>=98% by SDS-PAGE gel and HPLC analyses.

Sterile filtered through a 0.2 micron filter. Lyophilized with no additives.

At -20°C

Authenticity: Verified by N-terminal and Mass Spectometry analyses (when applicable). Biological Activity: Determined by its ability to chemoattract human neutrophils using a concentration range of 20.0-100.0 ng/ml. Endotoxin: Endotoxin level is <0.1 ng/ug of protein (<1EU/ ug). Protein content: Verified by UV Spectroscopy and /or SDS- PAGE gel

Reconstitution: Centrifuge the vial prior to opening . Reconstitute in water to a concentration of 0.1-1.0 mg/mL. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, It is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA)and store in working aliquots at -20°C or -80°C .

Innate Immunity; Inflammation; Chemotaxis

Lungkine is a CXC chemokine that is expressed in lung epithelial cells and, to a lesser extent, in certain fetal tissues. No human homolog has been identified and a specific cell surface receptor has not yet been found. Lungkine expression in lung tissue is elevated in response to inflammation, at which time it acts to specifically recruit neutrophils and direct them into the lung airway. Recombinant murine Lungkine is a 16.3 kDa CXC chemokine consisting of 142 amino acid residues, including four conserved cysteine residues present in CXC chemokines.

7674364

Q9WVL7.1

Q9WVL7

Chemokine Signaling Pathway (99271); Chemokine Signaling Pathway (672435); Chemokine Signaling Pathway (96864); Cytokine-cytokine Receptor Interaction Pathway (83248); Cytokine-cytokine Receptor Interaction Pathway (460)

CXCL15: Chemotactic for neutrophils. May be involved in lung- specific neutrophil trafficking during normal and inflammatory conditions. Belongs to the intercrine alpha (chemokine CxC) family. Protein type: Chemokine. Cellular Component: extracellular space; extracellular region. Molecular Function: chemokine activity; CXCR chemokine receptor binding; cytokine activity. Biological Process: G-protein coupled receptor protein signaling pathway; neutrophil chemotaxis; positive regulation of leukocyte chemotaxis; hemopoiesis; response to lipopolysaccharide; immune response; inflammatory response; chemotaxis; regulation of cell proliferation

0.005 mg

125 USD

0.02 mg

195

0.1 mg

505

0.5 mg

1410

1 mg

2320