protein

Human DKK-3

MBS695610

0.002 mg

125 USD

Recombinant Protein

Human DKK-3

DKK-3

dickkopf-related protein 3; Dickkopf-related protein 3; dickkopf-related protein 3; dkk-3; hDkk-3; dickkopf-3; RIG-like 5-6; RIG-like 7-1; dickkopf 3 homolog; dickkopf homolog 3; regulated in glioma; dickkopf WNT signaling pathway inhibitor 3

DKK3; DKK3; RIG; REIC; REIC; Dickkopf-3; Dkk-3; hDkk-3

DKK3_HUMAN

Species Reactivity: Human

-20 degree C.

66346689

NP_001018067.1

NM_001018057.1

38,390 Da

This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. The expression of this gene is decreased in a variety of cancer cell lines and it may function as a tumor suppressor gene. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]

DKK3: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. Belongs to the dickkopf family. Protein type: Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 11p15.2. Cellular Component: extracellular space. Biological Process: anatomical structure morphogenesis; Wnt receptor signaling pathway; adrenal gland development; negative regulation of aldosterone biosynthetic process; negative regulation of transcription, DNA-dependent

0.002 mg

125 USD

0.01 mg

195