Anti-human IL-17F | MyBioSource MBS695057 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Anti-human IL-17F

catalog :

MBS695057

quantity :

0.05 mg

price :

185 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, ELISA, neutralization, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS695057

products type :

Antibody

products full name :

Anti-human IL-17F

products short name :

[IL-17F]

products name syn :

[Anti-Human IL-17F]

other names :

[Interleukin-17F; Interleukin-17F; interleukin-17F; cytokine ML-1; interleukin 17F; Cytokine ML-1]

products gene name :

[IL-17F]

other gene names :

[IL17F; IL17F; ML1; ML-1; CANDF6; IL-17F; IL-17F]

uniprot entry name :

IL17F_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

form :

A sterile filtered antibody solution was lyophilized from PBS, pH 7.2.

storage stability :

Store at -20°C.

tested application :

Neutralization, ELISA (EIA), Western Blot (WB)

app notes :

Neutralization: To yield one-half maximal inhibition [ND 50 ] of the biological activity of Human IL-17F (50.0 ng/ml), a concentration of 0.8-1.2 ug/ml of this antibody is required. Sandwich ELISA: To detect Human IL-17F by sandwich ELISA (using 100 ul/well antibody solution) a concentration of 0.5 - 2.0 ug/ml of this antibody is required. This antigen affinity purified antibody, in conjunction with Biotinylated Anti-Human IL-17F MBS695053 as a detection antibody, allows the detection of at least 2000-4000 pg/mL of recombinant Human IL-17F. Western Blot: To detect Human IL-17F by Western Blot analysis this antibody can be used at a concentration of 0.1 - 0.2 ug/ml. When used in conjunction with compatible secondary reagents the detection limit for recombinant Human IL-17F is 1.5 - 3.0 ng/lane, under either reducing or non-reducing conditions. Optimal dilutions should be determined by each laboratory for each application.

other info1 :

Immunogen: E.coli derived recombinant Human IL-17F (MBS695982). Preparation: Produced from sera of rabbits immunized with highly pure recombinant Human IL-17F. Anti-Human IL-17F specific antibody was purified by affinity chromatography employing and immobilized Human IL-17F matrix. Reconstitution: Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml.

products description :

Produced from sera of rabbits pre-immunized with highly pure (>98%) recombinant hIL-17F. Anti-Human IL-17F specific antibody was purified by affinity chromatography employing immobilized hIL-17F matrix.

ncbi gi num :

239938888

ncbi acc num :

Q96PD4.3

uniprot acc num :

Q96PD4

ncbi mol weight :

~150 kDa

ncbi pathways :

IL17 Signaling Pathway (920968); IL23-mediated Signaling Events Pathway (138000); Inflammatory Bowel Disease (IBD) Pathway (842771); Inflammatory Bowel Disease (IBD) Pathway (842797)

ncbi summary :

The protein encoded by this gene is a cytokine that shares sequence similarity with IL17. This cytokine is expressed by activated T cells, and has been shown to stimulate the production of several other cytokines, including IL6, IL8, and CSF2/GM_CSF. This cytokine is also found to inhibit the angiogenesis of endothelial cells and induce endothelial cells to produce IL2, TGFB1/TGFB, and monocyte chemoattractant protein-1. [provided by RefSeq, Jul 2008]

uniprot summary :

IL17F: Stimulates the production of other cytokines such as IL- 6, IL-8 and granulocyte colony-stimulating factor, and can regulate cartilage matrix turnover. Stimulates PBMC and T-cell proliferation. Inhibits angiogenesis. Defects in IL17F are the cause of familial candidiasis type 6 (CANDF6). CANDF6 is a rare disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans. Belongs to the IL-17 family. Protein type: Secreted, signal peptide; Secreted; Cytokine. Chromosomal Location of Human Ortholog: 6p12. Cellular Component: extracellular space; extracellular region. Molecular Function: protein homodimerization activity; hematopoietin/interferon-class (D200-domain) cytokine receptor binding; cytokine binding; cytokine activity. Biological Process: proteoglycan metabolic process; negative regulation of angiogenesis; regulation of interleukin-8 biosynthetic process; regulation of transforming growth factor beta receptor signaling pathway; regulation of granulocyte macrophage colony-stimulating factor biosynthetic process; lymphotoxin A biosynthetic process; cytokine biosynthetic process; regulation of interleukin-2 biosynthetic process; cartilage development; regulation of interleukin-6 biosynthetic process; positive regulation of transcription from RNA polymerase II promoter; inflammatory response. Disease: Candidiasis, Familial, 6

size1 :

0.05 mg

price1 :

185 USD

size2 :

0.1 mg

price2 :

215

more info or order :

MyBioSource product webpage