antibody

Mouse Anti-Human TREM-2

MBS692386

0.1 mg

490 USD

monoclonal

mouse

nonconjugated

[42E14]

Antibody

Mouse Anti-Human TREM-2

[TREM-2]

[triggering receptor expressed on myeloid cells 2 isoform 2; Triggering receptor expressed on myeloid cells 2; triggering receptor expressed on myeloid cells 2; triggering receptor expressed on myeloid cells 2; Triggering receptor expressed on monocytes 2]

[TREM-2]

[TREM2; TREM2; TREM-2; Trem2a; Trem2b; Trem2c; TREM-2]

Monoclonal

IgG2

[42E14]

Mouse

Human

219

Protein G chromatography

Lyophilized

Lyophilized samples are stable for 2 years from date of receipt when stored at -70 degree C. Reconstituted antibody can be aliquoted and stored frozen at < -20 degree C for at least for six months without detectable loss of activity.

FC

WB: 1:1000-2000

Reconstitution: Reconstitute the antibody with 500 ul sterile PBS and the final concentration is 200 ug/ml. Reconstitution Buffer: PBS . Remarks: This antibody recognizes human TREM-2 in direct ELISA and WB.

Antigen: Recombinant human TREM-2

This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse) immunized with recombinant human TREM-2.

425876764

NP_061838.1

NM_001271821.1

Q9NZC2

Adaptive Immune System Pathway (1269171); Axon Guidance Pathway (1270303); DAP12 Interactions Pathway (1269283); DAP12 Signaling Pathway (1269284); Developmental Biology Pathway (1270302); Immune System Pathway (1269170); Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway (1269201); Innate Immune System Pathway (1269203); Osteoclast Differentiation Pathway (193147); Osteoclast Differentiation Pathway (193096)

This gene encodes a membrane protein that forms a receptor signaling complex with the TYRO protein tyrosine kinase binding protein. The encoded protein functions in immune response and may be involved in chronic inflammation by triggering the production of constitutive inflammatory cytokines. Defects in this gene are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2012]

TREM2: May have a role in chronic inflammations and may stimulate production of constitutive rather than inflammatory chemokines and cytokines. Forms a receptor signaling complex with TYROBP and triggers activation of the immune responses in macrophages and dendritic cells. Defects in TREM2 are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL); also known as presenile dementia with bone cysts or Nasu-Hakola disease (NHD). PLOSL is a recessively inherited disease characterized by a combination of psychotic symptoms rapidly progressing to presenile dementia and bone cysts restricted to wrists and ankles. PLOSL has a global distribution, although most of the patients have been diagnosed in Finland and Japan, with an estimated population prevalence of 2x10(-6) in the Finns. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral. Chromosomal Location of Human Ortholog: 6p21.1. Cellular Component: integral to membrane; intracellular membrane-bound organelle; plasma membrane. Molecular Function: receptor activity. Biological Process: humoral immune response; innate immune response; positive regulation of antigen processing and presentation of peptide antigen via MHC class II; positive regulation of calcium-mediated signaling; positive regulation of peptidyl-tyrosine phosphorylation; regulation of immune response. Disease: Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy

0.1 mg

490 USD